GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE
Synonym(s):110952;Galβ1,3GalNAcβ1,4(Neu5Acα2,3)Galβ1,4Glcβ1,1 Ceramide, NH₄;Ganglioside GM1, monosialo;Ganglioside GM₁, Ammonium Salt, Bovine Brain - CAS 37758-47-7 - Calbiochem
- CAS NO.：37758-47-7
- Empirical Formula: C73H134N4O31
- Molecular Weight: 1563.85
- MDL number: MFCD00466936
- EINECS: 200-081-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-15 11:31:18
What is GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE?
Chemical properties
Off-white powder
The Uses of GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE
Ganglioside GM1 (Ovine Brain) has been used in the preparation of small unilamellar vesicles for fluorescence studies. It has also been used in liposome preparation for circular dichroism studies with human wild type?synuclein. It may be used as a standard lipid for electrospray ionization (ESI) mass spectrometry (MS) analysis.
What are the applications of Application
Ganglioside GM1 sodium salt is a specific receptor for cholera toxin
Definition
ChEBI: A sialotetraosylceramide consisting of a branched pentasaccharide made up from one sialyl residue, two galactose residues, one N-acetylgalactosamine residue and a glucose residue at the reducing end attached to N-stear ylsphingosine via a beta-linkage.
General Description
Ganglioside GM1 is referred as brain ganglioside. It is an acidic glycosphingolipid comprising N-acetylneuraminic acid or N-glycolylneuraminic acid residues. It is upregulated in developing brain. Ganglioside GM1 has five glycosyl units.
Biochem/physiol Actions
Ganglioside GM1 is a modulator of Ca2+ flux in plasmamembrane. It plays a key role in neuronal development and maturation and has neuroprotective functionality. GM1 ganglioside from ovine has many pharmaceutical applications and is regarded as an effective therapeutic for Huntington′s disease. Accumulation of GM1 in brain due to β-galactosidase enzyme deficiency is implicated in metabolic disorder, GM1 gangliosidosis.
Properties of GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE
| Melting point: | >182°C (dec.) |
| storage temp. | −20°C |
| solubility | chloroform/methanol (9:1): 10 mg/mL, clear, colorless |
| form | lyophilized powder |
| color | Off-White |
| Merck | 14,4364 |
Safety information for GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE
Computed Descriptors for GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE
| InChIKey | GTTLZSUWCRJZRC-CRQBLQEMSA-N |
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