Fmoc-O-(benzylphospho)-L-serine

Synonym(s):Fmoc-O-(benzylphospho)-L-serine;Fmoc-Ser(PO(OBzl)OH)-OH;N-α-Fmoc-O-benzyl-L-phosphoserine

CAS NO.：158171-14-3
Empirical Formula: C25H24NO8P
Molecular Weight: 497.43
MDL number: MFCD00797869
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:47:19

Fmoc-O-(benzylphospho)-L-serine Structural

What is Fmoc-O-(benzylphospho)-L-serine?

Chemical properties

White to off-white powder

The Uses of Fmoc-O-(benzylphospho)-L-serine

Building block for the synthesis of phosphoserine containing peptides.

The Uses of Fmoc-O-(benzylphospho)-L-serine

It can be applied in the synthesis of phosphopeptides. This derivative can be introduced using standard activation methods, such as PyBOP and TBTU. The monoprotected phosphoserine residue once incorporated is stable to piperidine. Using this reagent, even peptides containing multiple phosphorylation sites can be prepared efficiently by standard Fmoc SPPS methods. β-piperidinylalanine formation has been shown to occur during Fmoc deprotection of N-terminal Ser(PO(OBzl)OH), particularly under microwave conditions. This side reaction can be eliminated by using cyclohexylamine or DBU just for this Fmoc deprotection step .

What are the applications of Application

Fmoc-Ser(PO3BzlH)-OH is a compound used in phosphopeptide synthesis

Properties of Fmoc-O-(benzylphospho)-L-serine

Density	1.403±0.06 g/cm3(Predicted)
storage temp.	Store at -15°C to -25°C.
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
pka	1.42±0.50(Predicted)
color	White to off-white
Water Solubility	Slightly soluble in water.
BRN	7060483
CAS DataBase Reference	158171-14-3(CAS DataBase Reference)