Fmoc-O-(benzylphospho)-L-serine
Synonym(s):Fmoc-O-(benzylphospho)-L -serine;Fmoc-Ser(PO(OBzl)OH)-OH;N-α-Fmoc-O-benzyl-L-phosphoserine
- CAS NO.：158171-14-3
- Empirical Formula: C25H24NO8P
- Molecular Weight: 497.43
- MDL number: MFCD00797869
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:13
What is Fmoc-O-(benzylphospho)-L-serine?
Chemical properties
White to off-white powder
The Uses of Fmoc-O-(benzylphospho)-L-serine
Building block for the synthesis of phosphoserine containing peptides.
The Uses of Fmoc-O-(benzylphospho)-L-serine
It can be applied in the synthesis of phosphopeptides. This derivative can be introduced using standard activation methods, such as PyBOP and TBTU. The monoprotected phosphoserine residue once incorporated is stable to piperidine. Using this reagent, even peptides containing multiple phosphorylation sites can be prepared efficiently by standard Fmoc SPPS methods. β-piperidinylalanine formation has been shown to occur during Fmoc deprotection of N-terminal Ser(PO(OBzl)OH), particularly under microwave conditions. This side reaction can be eliminated by using cyclohexylamine or DBU just for this Fmoc deprotection step .
What are the applications of Application
Fmoc-Ser(PO3BzlH)-OH is a compound used in phosphopeptide synthesis
Properties of Fmoc-O-(benzylphospho)-L-serine
| Density | 1.403±0.06 g/cm3(Predicted) |
| storage temp. | Store at -15°C to -25°C. |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Powder |
| pka | 1.42±0.50(Predicted) |
| color | White to off-white |
| Water Solubility | Slightly soluble in water. |
| BRN | 7060483 |
| CAS DataBase Reference | 158171-14-3(CAS DataBase Reference) |
Safety information for Fmoc-O-(benzylphospho)-L-serine
Computed Descriptors for Fmoc-O-(benzylphospho)-L-serine
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