Fenaminosulf

Description

Introduced in 1955, fenaminosulf (1; Lesan; Dexon) was one of the first selective, systemic fungicides. It is active against Phycomycetes such as Pythium, Phytophthora, and Aphanomyces but has little or no effect on higher fungi belonging to the Ascomycetes or Basidiomycetes. Fenaminosulf has a relatively high water solubility (20,000 mgL^-1), a feature often associated with fungicides that specifically inhibit Oomycetes (3). Another important physicochemical property is photolytic instability, one of the reasons that fenaminosulf was developed as a seed dressing and soil fungicide (4).
As a consequence of acute toxicity , limited spectrum, and photo-instability, the use of fenaminosulf decreased (4), and it is now listed in The Pesticide Manual (5) among products that have been superseded. Although no longer used, it is included here for completeness, being the only example of a commercial fungicide that acts on complex I.
During its period of use, fenaminosulf, as wettable powder (WP), dust, or granular formulations, was employed as a seed dressing and soil-applied fungicide to control damping off and foot/root rots. Fenaminosulf-based products were used on a range of plants including vegetables, field crops, ornamentals, and turf.

The Uses of Fenaminosulf

Used in biological and pharmacological studies including:• ;Cloning and characterization of GABA transporter1• ;Activity of anti-RSV carbonucleosides2• ;Inhibition by fungicides of urea hydrolysis and nitrification of urea nitrogen in soil3

Definition

ChEBI: Fenaminosulf is an organic molecular entity.

General Description

Yellow-brown crystals or brown powder.

Air & Water Reactions

Dust may form an explosive mixture in air. Water soluble.

Reactivity Profile

Aqueous solutions are sensitive to exposure to light.

Fire Hazard

Flash point data are not available for Fenaminosulf. Fenaminosulf is probably combustible.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Experimental teratogenic effects. Human mutation data reported. Questionable carcinogen, A fungicide. When heated to decomposition it emits very toxic fumes of NOx, Na2O, and SOx