Febrifugine
- CAS NO.：24159-07-7
- Empirical Formula: C16H19N3O3
- Molecular Weight: 301.34
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-06-15 22:31:22
What is Febrifugine?
Description
Febrifugine is a quinazolinone alkaloid originally isolated from D. febrifuga that has antimalarial activity. It reduces parasitemia and decreases mortality in mice infected with the P. berghei strain NK65 when administered at a dose of 1 mg/kg per day beginning prior to or on the day of infection.
The Uses of Febrifugine
Febrifugine is a quinazoline alkaloid with significant antimalarial and anticancerous efficacy. Febrifugine is an NRF2 inhibitor, that works with halofuginone for the treatment of chemo- and radio-resistant forms of cancer. Febrifugine analogs also functions as antimalarial, anticancer agents and in the prevention of chicken coccidiosis.
Properties of Febrifugine
| Melting point: | 139-140°; mp 154-156° |
| alpha | D25 +6° (c = 0.5 in chloroform); D25 +28° (c = 0.5 in ethanol) |
| Density | 1.39 |
| storage temp. | 2-8°C |
| solubility | DMF: 1.5 mg/ml; DMSO: 3.0 mg/ml; Ethanol: 0.1 mg/ml; PBS (pH 7.2): 2.5 mg/ml |
| form | A crystalline solid |
| pka | 14.61±0.40(Predicted) |
| Boiling point: | 508.2±60.0 °C(Predicted) |
| color | White to off-white |
| CAS DataBase Reference | 24159-07-7 |
Safety information for Febrifugine
Computed Descriptors for Febrifugine
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