Ebrotidine
- CAS NO.：100981-43-9
- Empirical Formula: C14H17BrN6O2S3
- Molecular Weight: 477.42
- MDL number: MFCD00869998
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-20 10:51:09
What is Ebrotidine?
Description
Ebrocit was launched in Spain as a gastroprotective agent. It was prepared from 4-bromobenzenesulfonamide in two steps. Ebrocit's activity arises from its ability to antagonize histamine H2-receptors (the first of a new generation) showing 1.5-2.5 times higher affinity than Ranitidine and 2-fold greater affinity than cimetidine which correlates to an antisecretory potency of 1 times and 4-10 times respectively. Cytoand gastroprotection arises from increased gastric mucus production, enhanced physiochemical properties (decreased permeability of H+), and an increase in mucin glycosylation and sulfation. It acts on gastric mucosal EGF and PDGF receptor expression. Nitric oxide was also found to be involved. Ebrocit caused enhanced mucosal blood flow with anti H.pylori activity. It has diminished P450 binding which eliminates the possibility of mutagenic nitrosoamine formation.
Originator
Ferrer (Spain)
The Uses of Ebrotidine
Ebrotidine is a H2 receptor antagonist that has shown gastroprotective properties against gastric mucosal damange.
Definition
ChEBI: Ebrotidine is a sulfonamide.
brand name
Ebrocit
References
[1]. patel s s, wilde m i. ebrotidine. drugs, 1996, 51(6): 974-80; discussion 981.
[2]. romero a, gómez f, villamayor f, et al. study of the population of enterochromaffin-like cells in mouse gastric mucosa after long-term treatment with ebrotidine. toxicologic pathology, 1996, 24(2): 160-165.
Properties of Ebrotidine
| Melting point: | 142.5-146℃ |
| Boiling point: | 633.0±65.0 °C(Predicted) |
| Density | 1.73±0.1 g/cm3(Predicted) |
| storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 5.25±0.40(Predicted) |
| color | White to Off-White |
| Stability: | Light Sensitive |
Safety information for Ebrotidine
Computed Descriptors for Ebrotidine
New Products
N,O-Dimethylhydroxylamine hydrochloride DL-beta-(3-Bromophenyl)alanine N,N CARBONYL DIIMIDAZOLE 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid (R)-1-Benzyl-3-pyrrolidinecarbonitrile Bupropian related compound F Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A 2,2'-(5-methyl-1,3-phenylene)-di(2-Methylpropionitrile) 1-methyl amino-2,4-dinitro benzene 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol (R)-BoroLeu-(+)-Pinanediol-CF3COOH 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy Benzylcyanide 3,4 Dimethoxy Benzylcyanide 3-Hydroxypropionitrile 4-Bromo BenzylcyanideRelated products of tetrahydrofuran
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