Roxatidine
- CAS NO.：78273-80-0
- Empirical Formula: C17H26N2O3
- Molecular Weight: 306.4
- MDL number: MFCD00871807
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-08-06 15:14:14
What is Roxatidine?
Description
Roxatidine (78273-80-0) is a novel histamine H2 receptor antagonist.1?Suppresses inflammatory responses via inhibition of NFκB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages.2?Clinically useful agent for prevention and healing of gastric and duodenal ulcers and bleeding.3?Attenuates degradation of extracellular matrix in osteoarthritis models by inactivating the NFkB pathway.4
The Uses of Roxatidine
Anti-ulcerative.
References
1) Mills and Wood (1989),?The pharmacology of histamine H2-receptor antagonists; Methods Find. Exp. Clin. Pharmacol., 11 Suppl. 1?87 2) Cho?et al. (2011), Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages; J. Cell. Biochem.,?112?3648 3) Imaeda?et al.?(2011),?Effect of lansoprazole versus roxatidine on prevention of bleeding and promotion of ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia; J. Gastroenterol.,?46?1267 4) Ze?et al. (2017),?Roxatidine Attenuates Degradation of Extracellular Matrix;?Biomed. Pharmacother.,?95?1156
Properties of Roxatidine
| Melting point: | 59-60 °C |
| Boiling point: | 524.3±45.0 °C(Predicted) |
| Density | 1.137±0.06 g/cm3(Predicted) |
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | oil |
| pka | 13.34±0.10(Predicted) |
| color | Colorless to pale yellow |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| CAS DataBase Reference | 78273-80-0(CAS DataBase Reference) |
Safety information for Roxatidine
Computed Descriptors for Roxatidine
New Products
N,O-Dimethylhydroxylamine hydrochloride DL-beta-(3-Bromophenyl)alanine N,N CARBONYL DIIMIDAZOLE 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid (R)-1-Benzyl-3-pyrrolidinecarbonitrile Bupropian related compound F Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A 2,2'-(5-methyl-1,3-phenylene)-di(2-Methylpropionitrile) 1-methyl amino-2,4-dinitro benzene 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol (R)-BoroLeu-(+)-Pinanediol-CF3COOH 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy Benzylcyanide 3,4 Dimethoxy Benzylcyanide 3-Hydroxypropionitrile 4-Bromo BenzylcyanideRelated products of tetrahydrofuran
You may like
-
![6,6'-bis(difluoromethoxy)-2,2'-bis((3,4-dimethoxypyridin-2-yl)methylsulfinyl)-1H,1'H-5,5'-bibenzo[d]imidazole 98%](https://img.chemicalbook.in//Content/image/CP5.jpg)
6,6'-bis(difluoromethoxy)-2,2'-bis((3,4-dimethoxypyridin-2-yl)methylsulfinyl)-1H,1'H-5,5'-bibenzo[d]imidazole 98%View Details
2115779-15-0 -
4-bromo-1H-pyrazole-3-carboxylic acid 98%View Details
13745-17-0 -
230971-72-9 (1-((2'-(2-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol 98%View Details
230971-72-9 -
1941177-45-2 98%View Details
1941177-45-2 -
Isopropyl amine Hydrochloride 99%View Details
15572-56-2 -
19501-58-7 99%View Details
19501-58-7 -
Cyclopropane-1,1-dicarboxylic acid 99%View Details
598-10-7 -
230971-71-8 (1-((2'-(1-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol 98%View Details
230971-71-8