E3 ligase Ligand-Linker Conjugates 11
Synonym(s):(S,R,S)-AHPC-6-5-6-Cl;(2S,4R)-1-((S)-2-(6-((5-((6-Chlorohexyl)oxy)pentyl)oxy)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;Crosslinker–E3 Ligase ligand conjugate;Protein degrader building block for PROTAC research;Template for synthesis of targeted protein degrader
- CAS NO.：1835705-61-7
- Empirical Formula: C39H61ClN4O6S
- Molecular Weight: 749.44
- MDL number: MFCD31560481
- Update Date: 2025-12-10 09:00:29
What is E3 ligase Ligand-Linker Conjugates 11?
The Uses of E3 ligase Ligand-Linker Conjugates 11
Protein degrader builiding block (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Properties of E3 ligase Ligand-Linker Conjugates 11
| Boiling point: | 921.3±65.0 °C(Predicted) |
| Density | 1.152±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 14.08±0.40(Predicted) |
| form | Solid |
| color | Off-white to yellow |
Safety information for E3 ligase Ligand-Linker Conjugates 11
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for E3 ligase Ligand-Linker Conjugates 11
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