E3 ligase Ligand-Linker Conjugates 13
Synonym(s):(2S,4R)-1-((S)-2-(2-(2-(2-Azidoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;Crosslinker−E3 ligase ligand conjugate;Protein degrader building block for PROTAC research;Template for synthesis of targeted protein degrader;VH032 conjugate
- CAS NO.：2010159-45-0
- Empirical Formula: C28H39N7O6S
- Molecular Weight: 601.72
- MDL number: MFCD31807300
- Update Date: 2026-01-17 10:03:36
What is E3 ligase Ligand-Linker Conjugates 13?
The Uses of E3 ligase Ligand-Linker Conjugates 13
Protein degrader builiding block (S,R,S)-AHPC-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Properties of E3 ligase Ligand-Linker Conjugates 13
| storage temp. | 2-8°C |
| form | Liquid |
| color | Off-white to yellow |
Safety information for E3 ligase Ligand-Linker Conjugates 13
Computed Descriptors for E3 ligase Ligand-Linker Conjugates 13
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