E3 ligase Ligand-Linker Conjugates 7 Free Base
- CAS NO.：2010159-57-4
- Empirical Formula: C32H49N5O8S
- Molecular Weight: 663.83
- MDL number: MFCD31656715
- Update Date: 2025-12-05 14:33:18
What is E3 ligase Ligand-Linker Conjugates 7 Free Base?
Description
(S, R, S)-AHPC-PEG4-amine is a PROTAC linker that incorporates an E3 ligase ligand with a PEG4 unit to empower drug research & discovery. The amine group is reactive with NHS ester or carboxylic acid.
The Uses of E3 ligase Ligand-Linker Conjugates 7 Free Base
Protein degrader builiding block (S,R,S)-AHPC-PEG4-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Properties of E3 ligase Ligand-Linker Conjugates 7 Free Base
| Boiling point: | 901.7±65.0 °C(Predicted) |
| Density | 1.230±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in Water, DMSO, Methanol |
| pka | 13.54±0.46(Predicted) |
| form | Solid |
| color | White to off-white |
Safety information for E3 ligase Ligand-Linker Conjugates 7 Free Base
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for E3 ligase Ligand-Linker Conjugates 7 Free Base
New Products
tert-butyl 9-methoxy-3-azaspiro[5.5]undecane-3-carboxylate Boc-His-OH 4-Chloropyrrolo[2,3-d]-pyrimidine Ethyl N-(2- cyanoacetyl)carbamate 1-Chloro-4-Methyl-2-Nitrobenzene 4-Bromo-2-chlorobenzonitrile 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile 1,3-Diethyl-1,3-Diphenylurea Methyl 2-methylquinoline-6-carboxylate 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile Benzethonium Chloride Trenbolone Enanthate Prednisolone acetate Cisplatin Chlorodehydromethyl testosterone Ketoconazole 2,4-Difluoro-5-nitrobenzoicacid Methyl 2-oxo-2,3-dihydrobenzo[d]oxazole-7-carboxylate 3-Hydroxy-4-nitrobromobenzene 4-(2-Aminoethyl)-7-hydroxy-2H-chromoen-2-one 2-Ethyl-1,4-diaminobenzene 2-Ethylhexyl 4-aminobenzoate Fmoc-N-Me-Ala-OH Fmoc-N-Me-Ile-OHRelated products of tetrahydrofuran
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