DISOPYRAMIDE
Synonym(s):α-Diisopropylaminoethyl-α-phenylpyridine-2-acetamide
- CAS NO.:3737-09-5
- Empirical Formula: C21H29N3O
- Molecular Weight: 339.48
- MDL number: MFCD00057366
- EINECS: 223-110-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-19 15:37:50
What is DISOPYRAMIDE?
Absorption
Nearly complete
Toxicity
LD50=580 mg/kg in rats
Description
Structurally, disopyramide does not belong to any of the known classes of antiarrhythmics; however, being a drug of the class IA sodium channel blockers, it exhibits membranestabilizing action and increases the effective refractory period and duration of an action potential in the atrium and ventricles. It causes a decrease in contractability and excitability of the myocardium, slowing of conductivity, and suppression of sinoatride automatism.
The Uses of DISOPYRAMIDE
Disopyramide is used for preventing and restoring atrial and ventricular extrasystole and tachycardia in order to prevent atrial flutter and arrhythmia.
Indications
For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias. It is a Class Ia antiarrhythmic drug.
Background
A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
What are the applications of Application
Disopyramide is an antiarrhythmic (class IA) and a sodium channel blocker
Pharmacokinetics
Disopyramide is an anti-arrhythmic drug indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia that are life-threatening. At therapeutic plasma levels, disopyramide shortens the sinus node recovery time, lengthens the effective refractory period of the atrium, and has a minimal effect on the effective refractory period of the AV node. Little effect has been shown on AV-nodal and His-Purkinje conduction times or QRS duration. However, prolongation of conduction in accessory pathways occurs.
Metabolism
Hepatic
Properties of DISOPYRAMIDE
Melting point: | 94.5-950C |
Boiling point: | 475.43°C (rough estimate) |
Density | 1.0779 (rough estimate) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Soluble in DMSO (25 mg/ml) and Ethanol (>35 mg/mL) |
form | solid |
color | White |
Water Solubility | 6.17mg/L(22.5 ºC) |
Safety information for DISOPYRAMIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H302:Acute toxicity,oral H361:Reproductive toxicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for DISOPYRAMIDE
Abamectin manufacturer
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