2-Pyridylethylamine

Synonym(s):2-(2-Aminoethyl)pyridine

CAS NO.：2706-56-1
Empirical Formula: C7H10N2
Molecular Weight: 122.17
MDL number: MFCD00006367
EINECS: 220-295-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-27 23:07:48

What is 2-Pyridylethylamine?

Chemical properties

clear colorless to yellow liquid

The Uses of 2-Pyridylethylamine

2-(2-Aminoethyl)pyridine is used as active pharmaceutical ingredients.

Definition

ChEBI: An aminoalkylpyridine that is pyridine substituted by a ethanamino group at position 2.

Biological Activity

Low doses of histamine or H1R agonist 2-pyridylethylamine (2-PEA) into the knee-joint were found to decrease formalin-induced articular nociception in rats. The pharmacological blockade and neurotoxic ablation of cells expressing neuropeptide Y1 receptor (Y1R) in the spinal cord were able to prevent the antinociceptive effect produced by the intra-articular administration of the histamine H1 receptor (H1R) agonist, 2-pyridylethilamine (2-PEA), in the formalin-induced articular incapacitation in rats[1].

References

[1] Eduardo Souza-Silva. “Intra-articular injection of 2-pyridylethylamine produces spinal NPY-mediated antinociception in the formalin-induced rat knee-joint pain model.” Brain Research 1735 (2020): Article 146757.

Properties of 2-Pyridylethylamine

Melting point:	198-200 °C(Solv: ethanol (64-17-5))
Boiling point:	92-93 °C12 mm Hg(lit.)
Density	1.021 g/mL at 25 °C(lit.)
refractive index	n20/D 1.536(lit.)
Flash point:	213 °F
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	Liquid
pka	pK1: 4.24(+2);pK2: 9.78(+1) (25°C,μ=0.05)
Specific Gravity	1.021
color	Clear colorless to yellow
Water Solubility	Soluble in water (partly), and most common polar solvent. Insoluble in non-polar solvents, and oils.
Sensitive	Air Sensitive
BRN	111208
CAS DataBase Reference	2706-56-1(CAS DataBase Reference)
NIST Chemistry Reference	2-Pyridineethanamine(2706-56-1)
EPA Substance Registry System	2-Pyridineethanamine (2706-56-1)

Safety information for 2-Pyridylethylamine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.