Pheniramine maleate

Chemical properties

white powder

Originator

Trimeton Maleate, Schering ,US,1948

The Uses of Pheniramine maleate

Pheniramine, a H1-receptor antagonist, is an antihistamine with anticholinergic and sedative properties. Pheniramine is used to treat allergic conditions such as hay fever or urticaria.

The Uses of Pheniramine maleate

Antihistaminic;H1 antagonist

The Uses of Pheniramine maleate

A H1 histamine receptor antagonist.

The Uses of Pheniramine maleate

Used medicinally as an antihistaminic (merck).

What are the applications of Application

Pheniramine maleate salt is A H1 histamine receptor antagonist

Definition

ChEBI: Pheniramine maleate is an organic molecular entity.

Manufacturing Process

According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the 3-phenyl-3-(2-pyridyl)-N,Ndimethylpropylamine, BP 139°-142°C/1-2 mm. The maleate is produced by reaction with maleic acid.

Therapeutic Function

Antihistaminic

General Description

White powder with a faint amine-like odor. Melting point 107°C. pH (1% solution) 4.5-5.5. Used medicinally as an antihistaminic.

General Description

Pheniramine maleate, 2-[α-[2-dimethylaminoethyl]benzyl]-pyridine bimaleate (Trimeton,Inhiston), is a white crystalline powder, with a faint aminelikeodor, which is soluble in water (1:5) and very soluble inalcohol. This drug is the least potent member of the seriesand is marketed as the racemate. The usual adult dose is 20to 40 mg 3 times daily. It is available in certain combinationproducts.

Air & Water Reactions

Water soluble.

Reactivity Profile

Pheniramine maleate gives weakly acidic aqueous solutions. May react with strong oxidizing agents.

Fire Hazard

Flash point data are not available for Pheniramine maleate, but Pheniramine maleate is probably combustible.

Biochem/physiol Actions

Pheniramine maleate is a H1 histamine receptor antagonist. It is an alkylamine derivative. Structurally, pheniramine contains a chiral carbon atom with a hydrogen atom. Other substituents include the pyridyl, alkylamine and phenyl groups. It is used as an antiallergic drug for treating the common cold, respiratory allergies, urticaria, and systematic allergic reactions.