BrettPhosPalladacycle
Synonym(s):(BrettPhos) palladium(II) phenethylamine chloride;BrettPhos Palladacycle;BrettPhos precatalyst;Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′, 6′-triisopropyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II)
- CAS NO.：1148148-01-9
- Empirical Formula: C43H63ClNO2PPd
- Molecular Weight: 798.83
- MDL number: MFCD12545956
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 03:39:34
What is BrettPhosPalladacycle?
The Uses of BrettPhosPalladacycle
Application Guide for Palladium Catalyzed Cross-Coupling Reactions
Catalyst for:
- C,N-cross coupling of unprotected 3-halo-2-aminopyridines with primary and secondary amines
- Amination reaction
- N-arylation of aminophenols
General Description
BrettPhos Pd G1 is a Buchwald first generation (G1) palladacycle precatalyst that can be used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. The formation of the active Pd(0) species in the G1 precatalyst is easy to generate, requiring merely a deprotonation with a base. The resulting catalyst is very active, even at temperatures down to ?40 °C, and can be used in a variety of cross-coupling protocols.
Properties of BrettPhosPalladacycle
| Melting point: | 198-204 °C |
| form | Powder |
| color | white |
Safety information for BrettPhosPalladacycle
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for BrettPhosPalladacycle
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