RuPhos Pd G3
Synonym(s):(2-Dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate;RuPhos-G3-Palladacycle;RuPhos-Pd-G3
- CAS NO.：1445085-77-7
- Empirical Formula: C43H57NO5PPdS-
- Molecular Weight: 837.375141
- MDL number: MFCD22572684
- Update Date: 2026-01-13 11:14:36
What is RuPhos Pd G3?
The Uses of RuPhos Pd G3
RuPhos Pd G3 can be used as a pre-catalyst in the following protocols:
- Palladium-catalyzed Suzuki coupling of 5-p-toluenesulfonyltetrazoles with arylboronic acids to synthesize 1,5-disubstituted tetrazoles.
- Suzuki-Miyaura catalyst-transfer polycondensation (SCTP) of 3-alkylthiophenes in the presence of N-methylimidodiacetic (MIDA)-boronate monomers.
- Suzuki-Miyaura-cross-coupling of aminothiophenes.
General Description
RuPhos Pd G3 is a third generation (G3) Buchwald precatalyst that can be used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. It is air-, moisture-, and thermally-stable and is highly soluble in a wide range of common organic solvents. Some of its unique features include lower catalyst loadings, shorter reaction time, efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.
Properties of RuPhos Pd G3
| Melting point: | 188-196°C (decomposition) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | Powder |
| color | white |
| CAS DataBase Reference | 1445085-77-7 |
Safety information for RuPhos Pd G3
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H412:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for RuPhos Pd G3
| InChIKey | GYTUQNMMIUJBSP-UHFFFAOYSA-N |
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