Aurora Kinase Inhibitor II

CAS NO.：331770-21-9
Empirical Formula: C23H20N4O3
Molecular Weight: 400.43
MDL number: MFCD13191283
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-21 10:31:43

What is Aurora Kinase Inhibitor II?

Description

The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. Aurora kinase inhibitor II is a cell-permeable anilinoquinazoline that blocks the activity of Aurora A (IC₅₀ = 0.39 μM). In MCF-7 cells, it blocks proliferation with an IC₅₀ value of 1.25 μM.

What are the applications of Application

Aurora Kinase Inhibitor II is a potent and selective ARK inhibitor

Properties of Aurora Kinase Inhibitor II

Boiling point:	518.6±50.0 °C(Predicted)
Density	1.321±0.06 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	DMF:0.25(Max Conc. mg/mL);0.62(Max Conc. mM) DMF:PBS(pH7.2) (1:2):0.33(Max Conc. mg/mL);0.82(Max Conc. mM) DMSO:2.5(Max Conc. mg/mL);6.2(Max Conc. mM)
form	A crystalline solid
pka	13.01±0.70(Predicted)
color	White to yellow

Safety information for Aurora Kinase Inhibitor II

Computed Descriptors for Aurora Kinase Inhibitor II

New Products

8-Bromo-3-methyl xanthine 5-Chlorothiophene-2-carboxylic acid 2-(2-Ethoxyphenoxy)ethyl bromide 1,3-Dibromo-2,2-dimethoxypropane Maleic hydrazide 4-FLUOROBENZOYLACETONITRILE 3,4-Dihydroxyacetophenone 3,4-Dimethoxyacetophenone 4-Nitroacetophenone DL-Glutamic acid 3-Nitroacetophenone 4'-Chloro-3'-nitroacetophenone 3-Hydroxy-2-methylbenzoic acid 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 3-acetyl pyridine 4-FORMYL-N-CBZ-PIPERIDINE 2-pyridineacetonitrile 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Trenbolone acetate 4-Bromobenzaldehyde 4-bromo-2-ethyl-3-fluorobenzoic acid 6-(chloromethyl)pteridine-2,4-diamine monohydrochloride 2-Chlorophenyl diphenyl chloromethane