7,8,9,10-Tetrahydro-benzo[a]pyren-7-ol

Description

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is a benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters, which are capable of forming covalent DNA adducts and inducing mutations.

Chemical properties

Yellow Solid

The Uses of 7,8,9,10-Tetrahydro-benzo[a]pyren-7-ol

7,8,9,10-Tetrahydro-benzo[a]pyren-7-ol is a Benzopyrene (B205800) derivative, activated by hepatic cytosol.

The Uses of 7,8,9,10-Tetrahydro-benzo[a]pyren-7-ol

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is a benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters, which are capable of forming covalent DNA adducts and inducing mutations.[Cayman Chemical]

What are the applications of Application

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is an oxygen compound used for research purposes

General Description

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol (7-hydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene), a polycyclic aromatic hydrocarbon (PAH), is a substituted benzopyrene. Its bromination reaction with N-bromosaccharin (NBSac) has been investigated. The sulfotransferase-assisted activation of 7-hydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene to form electrophilic, mutagenic, or tumorigenic sulfuric acid ester metabolite, which binds covalently to DNA and leads to mutation, has been reported.