DMT-dT Phosphoramidite
Synonym(s):5′-O-(4,4′-dimethoxytrityl)-2′-deoxythymidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite];5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxythymidine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite];DMT-dT amidite;DMT-dT Phosphoramidite;Thymidine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
- CAS NO.：98796-51-1
- Empirical Formula: C40H49N4O8P
- Molecular Weight: 744.81
- MDL number: MFCD00055063
- EINECS: 685-410-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:26:56
What is DMT-dT Phosphoramidite?
The Uses of DMT-dT Phosphoramidite
5''-O-[Bis(4-Methoxyphenyl)phenylmethyl]-thymidine 3''-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a nucleotide and reactant used in the solid-phase synthesis of phosphorothioate oligonucleotides, and in the synthesis of lipophilic 5''-phosphoramidate derivatives of DNA and RNA oligonucleotides.
Chemical properties
5'-O-DMT-Thymidine-CE Phosphoramidite is also known as DMT-dT Phosphoramidite. The IUPAC Name of this compound is (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite. It allows for the introduction of thymidine units into oligonucleotides. Also, it has been used in various applications, including the synthesis of natural and unnatural DNA and RNA strands.
The Uses of DMT-dT Phosphoramidite
5''-O-[Bis(4-Methoxyphenyl)phenylmethyl]-thymidine 3''-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a nucleotide and reactant used in the solid-phase synthesis of phosphorothioate oligonucleotides, and in the synthesis of lipophilic 5''-phosphoramidate derivatives of DNA and RNA oligonucleotides.
Properties of DMT-dT Phosphoramidite
| Density | 1.22 at 20℃ |
| vapor pressure | 0-0Pa at 20-50℃ |
| storage temp. | Sealed in dry,2-8°C |
| solubility | soluble, clear |
| form | powder or granules |
| pka | 9.55±0.10(Predicted) |
| color | white to off-white |
Safety information for DMT-dT Phosphoramidite
Computed Descriptors for DMT-dT Phosphoramidite
| InChIKey | UNOTXUFIWPRZJX-DJKSPSSYNA-N |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)C[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,38,r| |
DMT-dT Phosphoramidite manufacturer
DR ACHARYA LABORATORIES PVT LTD
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