5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole
- CAS NO.：124750-53-4
- Empirical Formula: C33H26N4
- Molecular Weight: 478.59
- MDL number: MFCD00665220
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-24 18:11:55
What is 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole?
Chemical properties
Off-white Solid
The Uses of 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole
An intermediate in the preparation of labelled Candesartan.
The Uses of 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole
5-?(4''-?Methyl-?[1,?1''-?biphenyl]?-?2-?yl)?-?1-?trityl-?1H-?tetrazole is a reactant in the synthesis of anti-microbial agents.
Synthesis
5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole is prepared by the reaction of trityl chloride and 2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl. The specific synthesis steps are as follows:
Dissolve compound 2 (200 g) with stirring at 40°C 700mL of acetone, Aqueous sodium hydroxide solution (40.67 g sodium hydroxide dissolved in 160 mL water) is added, Continue stirring for 1h, A solution of triphenylchloromethane in acetone (270.8 g of triphenylmethyl chloride dissolved in 800 mL of acetone) was initially added dropwise. The solid was added dropwise and gradually evolved into a white turbid liquid. The reaction was monitored by TLC until it was completely filtered off and washed with water to give a solid as intermediate 3. The solid was blow dried at 50°C to give white intermediate 3 (385 g), yield: 95.2%, HPLC: 99.44%.
Properties of 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole
| Melting point: | 166-169 °C(Solv: ethyl acetate (141-78-6); dichloromethane (75-09-2)) |
| Boiling point: | 681.6±65.0 °C(Predicted) |
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly) |
| form | Solid |
| pka | 0.30±0.10(Predicted) |
| color | Off-White |
| CAS DataBase Reference | 124750-53-4(CAS DataBase Reference) |
Safety information for 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole
| Signal word | Danger |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. |
Computed Descriptors for 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole
5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole manufacturer
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product: 124750-53-4 5-(4'-METHYL-[1,1'-BIPHENYL]-2-YL)-1-TRITYL-1H- TETRAZOLE / PENULTIMATE IMPURITY 90 % Above
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