3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- CAS NO.：151266-23-8
- Empirical Formula: C5H4IN5
- Molecular Weight: 261.02
- MDL number: MFCD03787931
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-24 18:11:58
![3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Structural](https://img.chemicalbook.in/CAS/GIF/151266-23-8.gif)
What is 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine ?
The Uses of 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine acts as a reagent in the discovery and preparation of CHMFL-FLT3-122 as potent and orally available FLT3 kinase inhibitor for FLT3-ITD positive acute myeloid leukemia. Development and preparation of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.
Synthesis
A solution of 3H-pyrazolo[3,4-d]pyrimidin-4-amine (10 g, 0.074 mol) and n-iodo-succinamide (25 g, 0.111 mol) in DMF (80 mL) was heated to 80° C. overnight under an argon atmosphere. The resulting solid was filtered and rinsed with cold EtOH. The product was dried in vacuo overnight to yield 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (24 g, 100 per cent yield).
Properties of 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
| Boiling point: | 312.3±52.0 °C(Predicted) |
| Density | 2.92±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 10.50±0.20(Predicted) |
| color | White to Light yellow to Light orange |
| λmax | 282nm(lit.) |
| Sensitive | Light Sensitive |
| InChI | InChI=1S/C5H4IN5/c6-3-2-4(7)8-1-9-5(2)11-10-3/h1H,(H3,7,8,9,10,11) |
Safety information for 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
| InChIKey | HQAIUXZORKJOJY-UHFFFAOYSA-N |
| SMILES | C1=NC(N)=C2C(I)=NNC2=N1 |
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine manufacturer
New Products
Methyl 2-hydroxy-3-nitrobenzoate 1,3-Diethyl-1,3-Diphenylurea 2,4-dihydroxybenzaldehyde 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 1,3-Di Iodo Benzene Methyl 2-oxo-2,3-dihydrobenzo[d]oxazole-7-carboxylate 4-(2-Aminoethyl)-7-hydroxy-2H-chromoen-2-one 3-Hydroxy-4-nitrobromobenzene 2-Ethyl-1,4-diaminobenzene 2-Ethylhexyl 4-aminobenzoate Thio AcetamideRelated products of tetrahydrofuran
![5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine](https://img.chemicalbook.in/CAS/GIF/22276-95-5.gif)
![4-Aminopyrazolo[3,4-d]pyrimidine](https://img.chemicalbook.in/CAS/GIF/2380-63-4.gif)
![4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE](https://img.chemicalbook.in/CAS/GIF/479633-63-1.gif)
![Pyrrolo[2,3-d]pyrimidin-4-ol](https://img.chemicalbook.in/CAS/GIF/3680-71-5.gif)
![4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine](https://img.chemicalbook.in/CAS/GIF/123148-78-7.gif)
![2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE](https://img.chemicalbook.in/CAS/GIF/63200-54-4.gif)
You may like
-
![3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine 98%](https://img.chemicalbook.in//ProductImageIndia/2024-03/Raw/c8b64ab5-7762-4c56-8643-29b03d5bbc96.png)
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine 98%View Details -
![3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine 98%](https://img.chemicalbook.in//Content/image/CP5.jpg)
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine 98%View Details
151266-23-8 -
4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine 151266-23-8 98%View Details
151266-23-8 -
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine CAS 151266-23-8View Details
151266-23-8 -
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine CASView Details
-
Powder 3 Iodo 1H Pyrazolo 3 4 D Pyrimidin 4 AmineView Details
151266-23-8 -
4-Amino-3-Iodo-1h-Pyrazolo(3,4,-D)-PyrimidineView Details
151266-23-8 -
151266-23-8 97-99%View Details
151266-23-8
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.