3,5-Lutidine

Synonym(s):3,5-Dimethylpyridine

CAS NO.：591-22-0
Empirical Formula: C7H9N
Molecular Weight: 107.15
MDL number: MFCD00006404
EINECS: 209-708-6
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:20:04

What is 3,5-Lutidine ?

Chemical properties

CLEAR YELLOW LIQUID

The Uses of 3,5-Lutidine

3,5-Lutidine is a reactant used in the synthesis of phthalazine and pyrazine compounds, as well as other pharmaceuticals.

Synthesis Reference(s)

Synthesis, p. 573, 1994 DOI: 10.1055/s-1994-25526

Flammability and Explosibility

Flammable

Purification Methods

Dry 3,5-lutidine with sodium and fractionally distil it through a Todd column (p 11) packed with glass helices. Dissolve (100mL) in dilute HCl (1:4) and steam distil this until 1L of distillate is collected. Excess conc NaOH is added to the residue which is again steam distilled. The base is extracted from the distillate, using diethyl ether. The extract is dried over K2CO3, and distilled. It is then fractionally crystallised by partial freezing. The hydrochloride has m 229o(sublimes at 190-231o), and the picrate has m 242-243o(dec, from H2O), 249-250o(dec, from AcOH). [Beilstein 20 II 161, 20 III/IV 2788, 20/6 V 60.]

Properties of 3,5-Lutidine

Melting point:	-9 °C (lit.)
Boiling point:	169-170 °C (lit.)
Density	0.939 g/mL at 25 °C (lit.)
vapor pressure	1.5 mm Hg ( 20 °C)
refractive index	n20/D 1.504(lit.)
Flash point:	128 °F
storage temp.	2-8°C
solubility	Sol
form	Liquid
pka	6.15(at 25℃)
color	Clear yellow
Water Solubility	33 g/L (20 ºC)
Sensitive	Hygroscopic
BRN	105682
CAS DataBase Reference	591-22-0(CAS DataBase Reference)
NIST Chemistry Reference	Pyridine, 3,5-dimethyl-(591-22-0)
EPA Substance Registry System	3,5-Dimethylpyridine (591-22-0)

Safety information for 3,5-Lutidine

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H226:Flammable liquids H302:Acute toxicity,oral H314:Skin corrosion/irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.