3-Trifluoromethoxyphenylboronic acid

Synonym(s):3-Trifluoromethoxybenzeneboronic acid

almost white to slightly beige powder and chunk

suzuki reaction

3-(Trifluoromethyloxy)phenylboronic Acid is used as a reagent in the preparation of pyrrolo[1,2-a]pyrazinones as inhibitors of PIM kinases.

Precursor commonly used in the synthesis of biologically active compounds including:

Multisubstituted purines for use as P2X7 antagonists in the treatment of pain
Heteroaryl substituted tetrahydropyrroloijquinolinone derivatives as aldosterone synthase inhibitors
Fluorohydroquinolineethanol as a CETP inhibitor
Biaryl amides with muscarinic acetylcholine receptor subtype M1 agonist activity
C2-aryl pyrrolobenzodiasepine antitumor agents
Piperazine-bisamide for obesity treatments

Melting point:	84-89 °C (lit.)
Boiling point:	266.6±50.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Powder and Chunks
pka	7.39±0.10(Predicted)
color	Almost white to slightly beige
BRN	7531456
CAS DataBase Reference	179113-90-7(CAS DataBase Reference)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.