3-Hydroxy-1-methylpiperidine
Synonym(s):1-Methyl-3-piperidinol;3-Hydroxy-1-methylpiperidine
- CAS NO.：3554-74-3
- Empirical Formula: C6H13NO
- Molecular Weight: 115.17
- MDL number: MFCD00006495
- EINECS: 222-609-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:30
What is 3-Hydroxy-1-methylpiperidine?
The Uses of 3-Hydroxy-1-methylpiperidine
Reactant for:• ;Optimization of Novobiocin scaffold to produce antitumor agents1• ;Formation of carbamates and N-alkylimidazoles2Reactant for synthesis of:• ;Pyridine derivatives as CDK5 inhibitors3• ;Phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors4• ;Amino phosphite ligands5• ;Mexiletine enantiomers by nucleophilic aromatic substitution6
The Uses of 3-Hydroxy-1-methylpiperidine
Reactant for Optimization of Novobiocin scaffold to produce antitumor agents, Formation of carbamates and N-alkylimidazoles. Reactant for synthesis of Pyridine derivatives as CDK5 inhibitors Phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors, Amino phosphite ligands, Mexiletine enantiomers by nucleophilic aromatic substitution.
The Uses of 3-Hydroxy-1-methylpiperidine
Reactant for:
- Optimization of Novobiocin scaffold to produce antitumor agents
- Formation of carbamates and N-alkylimidazoles
Reactant for synthesis of:
- Pyridine derivatives as CDK5 inhibitors
- Phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors
- Amino phosphite ligands
- Mexiletine enantiomers by nucleophilic aromatic substitution
Properties of 3-Hydroxy-1-methylpiperidine
| Boiling point: | 76-78 °C11 mm Hg(lit.) |
| Density | 0.999 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 158 °F |
| pka | 14.95±0.20(Predicted) |
| color | Clear, orange |
| Water Solubility | Fully misicible in water. |
| BRN | 103017 |
| CAS DataBase Reference | 3554-74-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-Piperidinol, 1-methyl-(3554-74-3) |
| EPA Substance Registry System | 3-Piperidinol, 1-methyl- (3554-74-3) |
Safety information for 3-Hydroxy-1-methylpiperidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 3-Hydroxy-1-methylpiperidine
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