3-Hydroxypyridine

Synonym(s):3-Pyridinol;3-Pyridone

CAS NO.：109-00-2
Empirical Formula: C5H5NO
Molecular Weight: 95.1
MDL number: MFCD00006378
EINECS: 203-637-4
SAFETY DATA SHEET (SDS)
Update Date: 2025-03-31 20:14:24

What is 3-Hydroxypyridine?

Chemical properties

white to light yellow crystal. Soluble in alcohol and water, slightly soluble in ether and benzene. It becomes a red solution when it encounters ferric chloride, and it is easy to decompose in the air.

The Uses of 3-Hydroxypyridine

3-Hydroxypyridine (cas# 109-00-2) is a compound useful in organic synthesis.

Definition

ChEBI: 3-Hydroxypyridine is a monohydroxypyridine that is pyridine in which the hydrogen at position 3 has been replaced by a hydroxy group. It has been detected as a thermal degradation product from the smoke of the burning leaves of Salvia divinorum, a Mexican psychoactive plant.

Preparation

3-hydroxypyridine was prepared by reacting furfurylamine with H2O2 in the presence of HCl, followed by hydrolysis. The optimal conditions were found as fellows: molar ratio of furfurylamine: HCl : H2O2 = 1 : 5 : 1.1, and H2O2 added dropwisely at 0-5 °C, and then refluxed at 100-105 °C for 0.5 h.

brand name

Ventavis (Schering).

Purification Methods

Crystallise 3-hydroxypyridine from *C6H6, water or EtOH. [Beilstein 21 III/IV 402, 21/2 V 68.]

Properties of 3-Hydroxypyridine

Melting point:	125-128 °C (lit.)
Boiling point:	280-281 °C(lit.)
Density	1.1418 (rough estimate)
refractive index	1.5939 (estimate)
Flash point:	173°C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	33g/l
form	Crystalline Powder
pka	4.79, 8.75(at 20℃)
color	Beige to brown
PH	6.0-6.5 (33g/l, H2O, 20℃)
Water Solubility	32.26g/L(20 ºC)
BRN	105699
CAS DataBase Reference	109-00-2(CAS DataBase Reference)
NIST Chemistry Reference	3-Pyridinol(109-00-2)
EPA Substance Registry System	3-Pyridinol (109-00-2)

Safety information for 3-Hydroxypyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.