2-Amino-3-hydroxypyridine
Synonym(s):2-Amino-3-pyridinol
- CAS NO.：16867-03-1
- Empirical Formula: C5H6N2O
- Molecular Weight: 110.11
- MDL number: MFCD00006317
- EINECS: 240-886-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-15 13:03:24
What is 2-Amino-3-hydroxypyridine?
Chemical properties
white to light yellow crystal powder
The Uses of 2-Amino-3-hydroxypyridine
2-Amino-3-hydroxypyridine was used as reagent in reaction of dimethyl acetylenedicarboxylate and triphenylphosphine to yield functionalized coumarins and 1,4-oxazines.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 14, p. 203, 1977 DOI: 10.1002/jhet.5570140206
General Description
2-Amino-3-hydroxypyridine forms complexes with number of transition metals. It inhibits the corrosion of aluminium and copper in acidic solutions. It undergoes condensation with 2-hydroxy-1-naphthaldehyde and 2-hydroxybenzaldehyde to form Schiffs bases. It is useful in the preparation of clinical anti-inflammatory analgesics.
Properties of 2-Amino-3-hydroxypyridine
| Melting point: | 168-172 °C (lit.) |
| Boiling point: | 206.4°C (rough estimate) |
| Density | 1.2111 (rough estimate) |
| vapor pressure | 0.007-0.28Pa at 20-50℃ |
| refractive index | 1.4800 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Crystalline Powder |
| pka | 5.15±0.10(Predicted) |
| color | Grayish-beige to brownish |
| BRN | 109868 |
| CAS DataBase Reference | 16867-03-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Amino-3-hydroxypyridine(16867-03-1) |
Safety information for 2-Amino-3-hydroxypyridine
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Amino-3-hydroxypyridine
| InChIKey | BMTSZVZQNMNPCT-UHFFFAOYSA-N |
2-Amino-3-hydroxypyridine manufacturer
JSK Chemicals
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GK Chemicals
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Lorven Biologics Pvt Ltd
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product: 16867-03-1 3-Hydroxy 2-Amino pyridine 98%
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