2,3,5,6-TETRAFLUORO-4-PYRIDINE-CARBONITRILE

CAS NO.：16297-07-7
Empirical Formula: C6F4N2
Molecular Weight: 176.07
MDL number: MFCD00075302
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 01:54:46

What is 2,3,5,6-TETRAFLUORO-4-PYRIDINE-CARBONITRILE?

The Uses of 2,3,5,6-TETRAFLUORO-4-PYRIDINE-CARBONITRILE

2,3,5,6-Tetrafluoro-4-pyridinecarbonitrile may be used in the preparation of 2-anilino-3,5,6-trifluoroisonicotinonitrile.

General Description

2,3,5,6-Tetrafluoro-4-pyridinecarbonitrile is a perfluorinated heteroaromatic compound. 2,3,5,6-Tetrafluoro-4-pyridinecarbonitrile (tetrafluoro-4-cyanopyridine) reacts with 1,3-dicarbonyl systems to yield the corresponding [5,6]-ring fused furo derivatives. 2,3,5,6-Tetrafluoro-4-pyridinecarbonitrile (4-cyanotetrafluoropyridine) reacts with amidines to yield [6,6]-fused pyrimidinopyridine system via nucleophilic substitution at the C-3 position of the pyridine ring followed by intramolecular cyclization onto the pendant cyano group. Reaction of 2,3,5,6-tetrafluoro-4-pyridinecarbonitrile (4-cyanotetrafluoropyridine) with sulfur centred nucleophiles has been reported.

Properties of 2,3,5,6-TETRAFLUORO-4-PYRIDINE-CARBONITRILE

Melting point:	66-68 °C (lit.)
Boiling point:	166.1±35.0 °C(Predicted)
Density	1.56±0.1 g/cm3(Predicted)
pka	-14.32±0.28(Predicted)
form	crystalline powder
color	White

Safety information for 2,3,5,6-TETRAFLUORO-4-PYRIDINE-CARBONITRILE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.