3,5-Difluoropyridine

CAS NO.：71902-33-5
Empirical Formula: C5H3F2N
Molecular Weight: 115.08
MDL number: MFCD03412222
EINECS: 624-636-9
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:21:44

What is 3,5-Difluoropyridine?

Chemical properties

Liquid

Preparation

Synthesis of 3,5-Difluoropyridine: A solution of 2,4,6-tribromo-3,5-difluoropyridine (11) (34.0 g, 97 mmol) in DCM (200 cm3) was washed with activated carbon and filtered. A palladium catalyst (3.4 g of a 5% Pd/C commercially available product) and triethylamine (45 cm3, 31.5 g, 312 mmol) were added to the filtrate and the mixture hydrogenated in a Parr apparatus at 4 Bar for 21 h. The mixture was filtered, water (200 cm3) added and extracted into DCM. Distillation of the DCM solution on Fischer-Spaltrohr apparatus gave 3,5-difluoropyridine (7.0 g, 61 mmol, 63%), b.p. 92.5 ·c (Found: C, 52.2; H, 3.0; N, 12.2. C5H3F2N2 requires C, 52.2; H, 3.0; N, 12.2%);
IR spectrum no. 1; mass spectrum no. 1; nrnr spectrum no. 8.

Properties of 3,5-Difluoropyridine

Boiling point:	92-93°C
Density	1.256 g/mL at 25 °C
refractive index	1.4437
Flash point:	9°C
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	clear liquid
pka	0.39±0.20(Predicted)
color	Colorless to Almost colorless
BRN	7914363
CAS DataBase Reference	71902-33-5(CAS DataBase Reference)

Safety information for 3,5-Difluoropyridine

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.