2-Methylpiperidine
Synonym(s):α-Pipecoline;2-Pipecoline;NSC 31047;NSC 462
- CAS NO.：109-05-7
- Empirical Formula: C6H13N
- Molecular Weight: 99.17
- MDL number: MFCD00005982
- EINECS: 203-642-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 17:23:55
What is 2-Methylpiperidine?
Chemical properties
Colorless to yellow liquid; pepper-like aroma.
Chemical properties
CLEAR YELLOW LIQUID
The Uses of 2-Methylpiperidine
Reactant for C-2 arylation of piperidines through directed transition metal-catalyzed sp3 C-H activation1Reactant for synthesis of:• ;Azepan-4-ones via two step [5+2] annulation2• ;2-Aminobenzoxazoles3• ;Unsymmetrically substituted ureas4• ;Corticotropin-releasing factor receptor type 1 antagonists5• ;Gefitinib analogues with anti-tumor activity6
The Uses of 2-Methylpiperidine
2-Methylpiperidine, is used for the oxidation of secondary amines to nitrones by means of H2O2 catalyzed by Sodium tungsten oxide dihydrate.
Definition
ChEBI: 2-Methylpiperidine is a member of piperidines.
Aroma threshold values
High strength; ammoniacal type; recommend smelling in a 1.0% solution or less.
Taste threshold values
Amine, creamy, taco, lettuce taste at 5 ppm in water.
Synthesis Reference(s)
Journal of the American Chemical Society, 111, p. 4108, 1989 DOI: 10.1021/ja00193a056
Properties of 2-Methylpiperidine
| Melting point: | -4--5 °C |
| Boiling point: | 118-119 °C/753 mmHg (lit.) |
| Density | 0.844 g/mL at 25 °C (lit.) |
| refractive index | n |
| FEMA | 4244 | 2-METHYLPIPERIDINE |
| Flash point: | 47 °F |
| storage temp. | Flammables area |
| form | Liquid |
| pka | pK1:10.95(+1) (25°C) |
| color | Clear yellow |
| Odor | at 1.00 % in propylene glycol. amine fishy seafood taco corn chip |
| PH | 12-13 (111g/l, H2O) |
| Water Solubility | soluble |
| JECFA Number | 1608 |
| BRN | 79804 |
| CAS DataBase Reference | 109-05-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Methylpiperidine(109-05-7) |
| EPA Substance Registry System | Piperidine, 2-methyl- (109-05-7) |
Safety information for 2-Methylpiperidine
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H225:Flammable liquids H302:Acute toxicity,oral H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Methylpiperidine
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