2-Methoxypyrazine
- CAS NO.：3149-28-8
- Empirical Formula: C5H6N2O
- Molecular Weight: 110.11
- MDL number: MFCD00006126
- EINECS: 221-579-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-17 20:01:48
What is 2-Methoxypyrazine?
Description
Methoxypyrazine has an odor threshold of 700 ppb in water. Methoxypyrazine may be prepared from 2-hydroxypyrazine by various routes.
Chemical properties
Colorless liquid
Chemical properties
Methoxypyrazine has a sweet, nutty, cocoa odor. Methoxypyrazine contributes a distinctive “green, capsicum (bell pepper), herbaceous and earthy” aroma that is quite characteristic of certain wines, such as sauvignon blanc and cabernet sauvignon.
Occurrence
Present at ultra-trace levels in sauvignon blanc and cabernet sauvignon grapes and wine. Methoxypyrazine contributes a distinctive wine aroma, even at low parts per trillion levels. Also reported found in cooked beef, cocoa, malt and krill.
Preparation
From 2-hydroxypyrazine by various routes.
Definition
ChEBI: Methoxypyrazine is an aromatic ether and a member of pyrazines.
Aroma threshold values
700 ppb in water
Safety Profile
Skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx.
Properties of 2-Methoxypyrazine
| Boiling point: | 60-61 °C/29 mmHg (lit.) |
| Density | 1.14 g/mL at 25 °C (lit.) |
| refractive index | n |
| FEMA | 3302 | METHOXYPYRAZINE |
| Flash point: | 114 °F |
| storage temp. | Sealed in dry,Room Temperature |
| form | clear liquid |
| pka | 0.53±0.10(Predicted) |
| Specific Gravity | 1.140 |
| color | Colorless to Almost colorless |
| Odor | at 1.00 % in dipropylene glycol. sweet nutty cocoa |
| JECFA Number | 787 |
| BRN | 2241 |
| CAS DataBase Reference | 3149-28-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyrazine, methoxy-(3149-28-8) |
| EPA Substance Registry System | Pyrazine, methoxy- (3149-28-8) |
Safety information for 2-Methoxypyrazine
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Methoxypyrazine
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