2-Methoxypyrazine

CAS NO.：3149-28-8
Empirical Formula: C5H6N2O
Molecular Weight: 110.11
MDL number: MFCD00006126
EINECS: 221-579-8
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 02:12:11

What is 2-Methoxypyrazine?

Description

Methoxypyrazine has an odor threshold of 700 ppb in water. Methoxypyrazine may be prepared from 2-hydroxypyrazine by various routes.

Chemical properties

Colorless liquid

Chemical properties

Methoxypyrazine has a sweet, nutty, cocoa odor. Methoxypyrazine contributes a distinctive “green, capsicum (bell pepper), herbaceous and earthy” aroma that is quite characteristic of certain wines, such as sauvignon blanc and cabernet sauvignon.

Occurrence

Present at ultra-trace levels in sauvignon blanc and cabernet sauvignon grapes and wine. Methoxypyrazine contributes a distinctive wine aroma, even at low parts per trillion levels. Also reported found in cooked beef, cocoa, malt and krill.

Preparation

From 2-hydroxypyrazine by various routes.

Definition

ChEBI: Methoxypyrazine is an aromatic ether and a member of pyrazines.

Aroma threshold values

700 ppb in water

Safety Profile

Skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx.

Properties of 2-Methoxypyrazine

Boiling point:	60-61 °C/29 mmHg (lit.)
Density	1.14 g/mL at 25 °C (lit.)
refractive index	n20/D 1.509(lit.)
FEMA	3302 \| METHOXYPYRAZINE
Flash point:	114 °F
storage temp.	Sealed in dry,Room Temperature
form	clear liquid
pka	0.53±0.10(Predicted)
Specific Gravity	1.140
color	Colorless to Almost colorless
Odor	at 1.00 % in dipropylene glycol. sweet nutty cocoa
JECFA Number	787
BRN	2241
CAS DataBase Reference	3149-28-8(CAS DataBase Reference)
NIST Chemistry Reference	Pyrazine, methoxy-(3149-28-8)
EPA Substance Registry System	Pyrazine, methoxy- (3149-28-8)

Safety information for 2-Methoxypyrazine

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.