Pyrazinamide
Synonym(s):2-Pyrazinecarboxamide;Pyrazinamide;Pyrazine-2-carboxamide;Pyrazinecarboxamide;Pyrazinoic acid amide
- CAS NO.:98-96-4
- Empirical Formula: C5H5N3O
- Molecular Weight: 123.11
- MDL number: MFCD00006132
- EINECS: 202-717-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:02:53
What is Pyrazinamide?
Absorption
Rapidly and well absorbed from the gastrointestinal tract.
Toxicity
Side effects include liver injury, arthralgias, anorexia, nausea and vomiting, dysuria,malaise and fever, sideroblastic anemia, adverse effects on the blood clotting mechanism or vascular integrity, and hypersensitivity reactions such as urticaria, pruritis and skin rashes.
Description
Pyrazinamide was synthesized in 1952, and it is the nitrogen-analog of nicotinamide. It exhibits hepatotoxicity. Synonyms of this drug are dexambutol, miambutol, esnbutol, ebutol, and others.
The Uses of Pyrazinamide
Pyrazinamide is used therapeutically as an antitubercular agent. Pyrazinamide is used to form polymeric copper complexes, create pyrazine carboxamide scaffolds useful as FXs inhibitors, and as a component of mycobacteria identification kits. It is used to study liver toxicity prevention and mechanisms of resistance .
Background
A pyrazine that is used therapeutically as an antitubercular agent.
Indications
For the initial treatment of active tuberculosis in adults and children when combined with other antituberculous agents.
What are the applications of Application
Pyrazinamide is an antibacterial agent used to study liver toxicity prevention
Pharmacokinetics
Pyrazinamide kills or stops the growth of certain bacteria that cause tuberculosis (TB). It is used with other drugs to treat tuberculosis. It is a highly specific agent and is active only against Mycobacterium tuberculosis. In vitro and in vivo, the drug is active only at a slightly acid pH. Pyrazinamie gets activated to Pyrazinoic acid in the bacilli where it interferes with fatty acid synthase FAS I. This interferes with the bacteriums ability to synthesize new fatty acids, required for growth and replication.
Metabolism
Hepatic.
Properties of Pyrazinamide
Melting point: | 189-191 °C (lit.) |
Boiling point: | 229.19°C (rough estimate) |
Density | 1.3260 (rough estimate) |
Flash point: | >110°(230°F) |
storage temp. | 2-8°C |
solubility | H2O: soluble50mg/mL |
form | Crystalline Powder or Needles |
color | White |
Water Solubility | 15 mg/mL |
Safety information for Pyrazinamide
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Pyrazinamide
Abamectin manufacturer
BIOCHEMICAL & SYNTHETIC PRODUCTS PVT. LT.,
Murli Krishna Exports Pvt Ltd
Calyx Chemicals and Pharmaceuticals Ltd
Dr. Silviu Pharmachem Pvt., Ltd.
Ralington Pharma
New Products
3-N-BOC-(S)-AMINO BUTYRONITRILE 4-Piperidinopiperidine N-Benzyl-3-hydroxypiperidine 2-Methyl-4-nitrobenzoic acid 2-(4-bromophenyl)-2-methylpropanoic acid 4-Acetyl-2-methylbenzoicacid Acetyl-meldrum's acid Ethyl-4-Pyrazole carboxylate 2,6-Pyridinedimethanol 5,7-Dichloro-3H-Imidazo[4,5-B]Pyridine 5-Bromo-2-Methoxy-4-Methyl-3-Nitropyridine 2-Fluoro-5-Iodopyridine 2-Fluoro-5-Methylpyridine 2-Chloro-3-Bromo-5-Amiopyridine METHYL-4-(BUTYRYLAMINO)3-METHYL-5-NITROBENZOATE TRANS-CYCLOBUTANE-1,2- DICARBOXYLIC ACID 5-Nitro indazole R-(-)-5-(2-AMINO-PROPYL)-2-METHOXY-BENZENESULFONAMIDE 1,3-cyclohexanedione 4-Aminophenaethylalchol (S)-(+)-4-BENZYL-2-OXAZOLIDINONE 3-NITRO-5-ACETYL IMINODIBENZYL 4-FLUORO PHENYL MAGNESIUM BROMIDE 1.0 M IN THF 1-HYDROXY-4-METHYL6-(2,4,4-TRI METHYL PHENYL)-2-PYRIDONE MONO ETHANOL AMINE(PIROCTONE OLAMINE)Related products of tetrahydrofuran
You may like
-
98-96-4 Pyrazinamide 99%View Details
98-96-4 -
PYRAZINAMIDE BP 99%View Details
-
Pyrazinamide 98-96-4 98%View Details
98-96-4 -
98-96-4 98%View Details
98-96-4 -
Pyrazinamide 98-96-4 98%View Details
98-96-4 -
98-96-4 98%View Details
98-96-4 -
Pyrazinamide 99%View Details
98-96-4 -
Pyrazinamide 98-96-4 98%View Details
98-96-4