2-Hydroxy-N-(4-hydroxyphenyl)-benzamide
Synonym(s):2-Hydroxy-N-(4-hydroxyphenyl)benzamide;4′-Hydroxysalicylanilide;Osalmide;Oxaphenamide;p-hydroxyphenylsalicylamide
- CAS NO.：526-18-1
- Empirical Formula: C13H11NO3
- Molecular Weight: 229.23
- MDL number: MFCD00020026
- EINECS: 208-385-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:40
What is 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide?
Definition
ChEBI: Osalmid is an organic molecular entity.
Biochem/physiol Actions
Osalmid is a potent inhibitor of ribonucleotide reductase small subunit M2 (RRM2) that potently inhibits HBV DNA and cccDNA synthesis in HepG2.2.15 cells. Osalmid inhibits RR (ribonucleotide reductase) activity in vivo, and exhibits synergistic effect with lamivudine on inactivation mutant HBV strain. Osalmid is a biliation activator (choleretic agent), but a mechanism of this activity remains unknown.
Properties of 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide
| Melting point: | 179° |
| Boiling point: | 371.13°C (rough estimate) |
| Density | 1.2084 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.5500 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO : ≥ 28 mg/mL (122.15 mM) |
| form | Solid |
| pka | 8.40±0.30(Predicted) |
| color | White to off-white |
| Water Solubility | 916mg/L at 25℃ |
| CAS DataBase Reference | 526-18-1(CAS DataBase Reference) |
| EPA Substance Registry System | Osalmid (526-18-1) |
Safety information for 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P501:Dispose of contents/container to..… |
Computed Descriptors for 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide
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