2-Hydroxy-N-(4-hydroxyphenyl)-benzamide

Synonym(s):2-Hydroxy-N-(4-hydroxyphenyl)benzamide;4′-Hydroxysalicylanilide;Osalmide;Oxaphenamide;p-hydroxyphenylsalicylamide

CAS NO.：526-18-1
Empirical Formula: C13H11NO3
Molecular Weight: 229.23
MDL number: MFCD00020026
EINECS: 208-385-9
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 00:43:18

2-Hydroxy-N-(4-hydroxyphenyl)-benzamide Structural

What is 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide?

Definition

ChEBI: Osalmid is an organic molecular entity.

Biochem/physiol Actions

Osalmid is a potent inhibitor of ribonucleotide reductase small subunit M2 (RRM2) that potently inhibits HBV DNA and cccDNA synthesis in HepG2.2.15 cells. Osalmid inhibits RR (ribonucleotide reductase) activity in vivo, and exhibits synergistic effect with lamivudine on inactivation mutant HBV strain. Osalmid is a biliation activator (choleretic agent), but a mechanism of this activity remains unknown.

Properties of 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide

Melting point:	179°
Boiling point:	371.13°C (rough estimate)
Density	1.2084 (rough estimate)
vapor pressure	0Pa at 25℃
refractive index	1.5500 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO : ≥ 28 mg/mL (122.15 mM)
form	Solid
pka	8.40±0.30(Predicted)
color	White to off-white
Water Solubility	916mg/L at 25℃
CAS DataBase Reference	526-18-1(CAS DataBase Reference)
EPA Substance Registry System	Osalmid (526-18-1)

Safety information for 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P501:Dispose of contents/container to..…