Rafoxanide

Synonym(s):3′-Chloro-4′-(4-chlorophenoxy)-3,5-diiodosalicylanilide

CAS NO.：22662-39-1
Empirical Formula: C19H11Cl2I2NO3
Molecular Weight: 626.01
MDL number: MFCD00682899
EINECS: 245-148-9
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-22 22:14:22

What is Rafoxanide?

Chemical properties

Rafoxanide is a white to off-white solid,it is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).The solubility of rafoxanide in ethanol is approximately 2 mg/ml and approximately 30 mg/ml in DMSO and DMF.

The Uses of Rafoxanide

Rafoxanide is a thyroid hormone receptor.

Synthesis

The method includes preparing 2-chloro-4-nitrophenyl tert-chlorophenyl ether by adopting p-chlorophenol and 3,4-dichloronitrobenzene as raw materials and adopting DMF as a solvent under catalysis of a catalyst that is cuprous chloride, preparing 4-amino-2-chlorophenyl tert-chlorophenyl ether by hydrogenating under catalysis of a 10% Pd/C catalyst, reacting 3,5-diiodosalicylic acid that is adopted as a raw material with an acyl chlorination reagent that is BTC/C2H4Cl2 to prepare 3,5-diiodosalicyloyl chloride, and subjecting the 4-amino-2-chlorophenyl tert-chlorophenyl ether and the 3,5-diiodosalicyloyl chloride to condensation to prepare the rafoxanide.

Properties of Rafoxanide

Melting point:	168-170°
Boiling point:	526.6±50.0 °C(Predicted)
Density	2.050±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form	neat
pka	6.04±0.48(Predicted)
form	Solid
color	White to Off-White
Merck	14,8097
CAS DataBase Reference	22662-39-1(CAS DataBase Reference)

Safety information for Rafoxanide

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H413:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment.