2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE
- CAS NO.：341-88-8
- Empirical Formula: C16H21NO2
- Molecular Weight: 259.34
- MDL number: MFCD00057295
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 03:55:12
What is 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE?
Description
HQNO (341-88-8) is a naturally occurring antagonist of dihydrostreptomycin. Potent inhibitor of the respiratory chain binding to the mitochondrial cytochrome b protein. HQNO inhibits NADH oxidase (NADH) and Na+-dependent NADH-quinone reductase (NQR).
The Uses of 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE
HQNO is a streptomycin antagonist. A naturally occurring antagonist of dihydrostreptomycin.
What are the applications of Application
HQNO is a high affinity respiratory chain inhibitor of quinone oxidation and Zn(II) described to reduce oxygen in and the activity of proton pumps.
Definition
ChEBI: 2-heptyl-4-hydroxyquinoline N-oxide is an inhibitor of the mitochondrial respiratory chain at cytochrome bc1 and of photosynthetic electron flow immediately before cytochrome b559. It is a monohydroxyquinoline and a quinoline N-oxide.
References
References/Citations 1) Nakayama?et al. (1999),?Inhibitor studies of a new antibiotic, korormicin, 2-n-heptyl-4-hydroxyquinoline N-oxide and Ag+?toward the Na+-translocating NADH-quinone reductase from the marine Vibrio alginolyticus; Biol. Pharm. Bull.,?221064
Properties of 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE
| Melting point: | 156-157° |
| Boiling point: | 445.8±37.0 °C(Predicted) |
| Density | 1.09±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Soluble in DMSO (up to 8 mg/ml with warming), or in Ethanol (up to 13 mg/ml with warming). |
| form | White to off-white crystalline solid. |
| pka | 1.07±0.40(Predicted) |
| color | White |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
Safety information for 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE
New Products
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