Pyridine-N-oxide
- CAS NO.：694-59-7
- Empirical Formula: C5H5NO
- Molecular Weight: 95.1
- MDL number: MFCD00006194
- EINECS: 211-774-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:23:39
What is Pyridine-N-oxide?
Chemical properties
White to light yellow solid
The Uses of Pyridine-N-oxide
Intermediate.
The Uses of Pyridine-N-oxide
Pyridine N-Oxide is a useful reagent for the chemical industry, a mild reoxidant that transforms osmium-catalyzed oxidative cyclization. A catalytic agent.
Definition
ChEBI: The pyridine N-oxide derived from the parent pyridine. It is a drug metabolite of the antihypertensive agent pinacidil.
Synthesis Reference(s)
Organic Syntheses, Coll. Vol. 4, p. 828, 1963
Tetrahedron Letters, 12, p. 2807, 1971 DOI: 10.1016/S0040-4039(01)97047-9
General Description
Pyridine N-oxide axle with [2]rotaxanes was synthesized via an anion templated threading-followed-by-stoppering strategy.
Hazard
Probably flammable and toxic.
Purification Methods
Purify the N-oxide by crystallisation from Et2O and by vacuum sublimation. The picrolonate has m 182-184o. [Katritzky J Chem Soc 2407 1956, Beilstein 20 III/IV 2305, 20/5 V 217.]
Properties of Pyridine-N-oxide
| Melting point: | 62-67 °C(lit.) |
| Boiling point: | 270 °C(lit.) |
| Density | 1.1418 (rough estimate) |
| refractive index | 1.5939 (estimate) |
| Flash point: | 143 °C |
| storage temp. | 2-8°C |
| form | Crystalline Solid, Crystals, and/or Chunks |
| pka | 0.79(at 24℃) |
| color | White to brownish |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| Merck | 14,7972 |
| BRN | 105257 |
| CAS DataBase Reference | 694-59-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyridine, 1-oxide(694-59-7) |
| EPA Substance Registry System | Pyridine, 1-oxide (694-59-7) |
Safety information for Pyridine-N-oxide
| Signal word | Warning |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Pyridine-N-oxide
Pyridine-N-oxide manufacturer
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