2-(Di-tert-butylphosphino)biphenyl
Synonym(s):(2-Biphenyl)di-tert-butylphosphine;(2-Biphenylyl)di-tert-butylphosphine;2-(Di-tert-butylphosphino)biphenyl
- CAS NO.：224311-51-7
- Empirical Formula: C20H27P
- Molecular Weight: 298.4
- MDL number: MFCD01862440
- EINECS: 607-074-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:25
What is 2-(Di-tert-butylphosphino)biphenyl?
Chemical properties
white to light yellow crystal powde
The Uses of 2-(Di-tert-butylphosphino)biphenyl
suzuki reaction
The Uses of 2-(Di-tert-butylphosphino)biphenyl
2-(Di-tert-butylphosphino)biphenyl (also known as JohnPhos) is a Buchwald ligand that is highly efficient in palladium-catalyzed reactions.
General Description
JohnPhos is a Buchwald′s sterically bulky biaryl phosphine ligand. It is a reactive dialkylbiaryl phosphine ligand which catalyzes the carbon-nitrogen bond-forming reactions. Coordination chemistry of gold catalysts bearing JohnPhos as ligand has been investigated by NMR spectroscopy.
Properties of 2-(Di-tert-butylphosphino)biphenyl
| Melting point: | 86-88 °C (lit.) |
| Boiling point: | 405.5±24.0 °C(Predicted) |
| Density | 1 g/cm3 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly, Heated, Sonic |
| form | Crystals or Crystalline Powder |
| color | White |
| Water Solubility | Insoluble |
| BRN | 8322131 |
| Stability: | Air Sensitive |
| CAS DataBase Reference | 224311-51-7(CAS DataBase Reference) |
Safety information for 2-(Di-tert-butylphosphino)biphenyl
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H413:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 2-(Di-tert-butylphosphino)biphenyl
| InChIKey | CNXMDTWQWLGCPE-UHFFFAOYSA-N |
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