2-CHLORO-4,4,5,5-TETRAMETHYL-1,3,2-DIOXAPHOSPHOLANE
- CAS NO.：14812-59-0
- Empirical Formula: C6H12ClO2P
- Molecular Weight: 182.59
- MDL number: MFCD00274239
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 04:31:54
What is 2-CHLORO-4,4,5,5-TETRAMETHYL-1,3,2-DIOXAPHOSPHOLANE?
Description
2-Chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane is an organic reagent commonly used in chemical and experimental research as a reagent for the phosphorylation of alcohols and heteroatoms for the formation of glycosyl donors and ligands, and in analytical studies of derivatised lignin samples. It is also used as a catalyst in CuO/TiO2 catalysed lignin oxidation studies.
Chemical properties
2-Chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane is an organic reagent in the physical state of a solid. Molecular weight: 182.59, Density: 1.149 g/cm3, Boiling point: 81.5-82° C (lit.) at 13 mmHg, Flash point: 113 °C, Refractive index: n20/D 1.471 (lit.), Store at 10°C-25°C, keep dry, under inert gas nitrogen.
The Uses of 2-CHLORO-4,4,5,5-TETRAMETHYL-1,3,2-DIOXAPHOSPHOLANE
2-Chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane (TMDP) can be used:
- As a reagent for the phosphitylation of alcohols and heteroatomic nucleophiles, resulting in the formation of useful glycosyl donors and ligands.
- As a phosphitylation reagent to derivatize lignin samples for 31P NMR analysis.
What are the applications of Application
2-Chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane is phosphitylator of alcohols and heteroatomic nucleophiles
Properties of 2-CHLORO-4,4,5,5-TETRAMETHYL-1,3,2-DIOXAPHOSPHOLANE
| Boiling point: | 81.5-82 °C13 mm Hg(lit.) |
| Density | 1.149 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
Safety information for 2-CHLORO-4,4,5,5-TETRAMETHYL-1,3,2-DIOXAPHOSPHOLANE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-CHLORO-4,4,5,5-TETRAMETHYL-1,3,2-DIOXAPHOSPHOLANE
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