2-Chloro-1,3,2-dioxaphospholane
Synonym(s):Cyclic ethylene chlorophosphite;Cyclic ethylene phosphorochloridite;Ethylene chlorophosphite;Ethylene glycol chlorophosphite
- CAS NO.：822-39-9
- Empirical Formula: C2H4ClO2P
- Molecular Weight: 126.48
- MDL number: MFCD00014511
- EINECS: 212-499-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:23:42
What is 2-Chloro-1,3,2-dioxaphospholane?
Chemical properties
Clear Colourless Oil
The Uses of 2-Chloro-1,3,2-dioxaphospholane
Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs
The Uses of 2-Chloro-1,3,2-dioxaphospholane
Ethylene chlorophosphite acts as a phosphitylating agent involved in the preparation of phosphocholine and spirophosphoranes. For example, it is used in the phosphorylation of p-tert-butyl(thia)calixarenes.
Properties of 2-Chloro-1,3,2-dioxaphospholane
| Melting point: | -28°C(lit.) |
| Boiling point: | 62 °C/20 mmHg (lit.) |
| Density | 1.422 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 158 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly) |
| form | clear liquid |
| color | Colorless to Light yellow |
| Sensitive | Moisture Sensitive |
| BRN | 506179 |
| Stability: | Extremely Moisture Sensitive |
| CAS DataBase Reference | 822-39-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethylene chlorophosphite(822-39-9) |
| EPA Substance Registry System | 1,3,2-Dioxaphospholane, 2-chloro- (822-39-9) |
Safety information for 2-Chloro-1,3,2-dioxaphospholane
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Chloro-1,3,2-dioxaphospholane
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