2-bromo-6beta,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate)
- CAS NO.：57781-14-3
- Empirical Formula: C25H29BrF2O7
- Molecular Weight: 559.39
- MDL number: MFCD00866011
- EINECS: 260-951-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:40
What is 2-bromo-6beta,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate)?
Originator
Topicon,Pierrel,Italy,1983
The Uses of 2-bromo-6beta,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate)
Anti-inflammatory (topical).
Definition
ChEBI: Halopredone acetate is an organic molecular entity.
Manufacturing Process
100 ml of a 70% hydrofluoric acid aqueous solution were cooled to -10°C in a polyethylene flask equipped with electromagnetic stirrer. 10 g of 2-bromo-6β- fluoro-17α,21-dihydroxy-9β, 11β-oxido-pregna-1,4-diene-3,20-dione-17,21- diacetate were added under stirring during 15 minutes. After 0.5 hour the reaction mixture was precipitated in water and ammonia. The solid was collected by filtration, washed with water and dried to a constant weight, giving about 9.5 g of 2-bromo-6β,9α-difluoro-11β,17α,21 -trihydroxypregna- 1,4-diene-3,20-dione-17,21-diacetate.
Therapeutic Function
Topical antiinflammatory
Properties of 2-bromo-6beta,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate)
| Melting point: | 290-292° (dec) |
| alpha | D24 -36° (c = 1 in chloroform) |
| Density | 1.3611 (rough estimate) |
| refractive index | 1.3760 (estimate) |
Safety information for 2-bromo-6beta,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate)
Computed Descriptors for 2-bromo-6beta,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate)
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