2'- and 3'-O-(4-Benzoylbenzoyl)-adenosine 5'-triphosphate triethylammonium salt

Synonym(s):;Benzoylbenzoyl-ATP;Bz-ATP;BzATP Triethylammonium Salt - CAS 112898-15-4 - Calbiochem

CAS NO.：112898-15-4
Empirical Formula: C24H24N5O15P3.C6H15N
Molecular Weight: 816.58
MDL number: MFCD00058547
SAFETY DATA SHEET (SDS)
Update Date: 2026-09-12 18:51:26

2'- and 3'-O-(4-Benzoylbenzoyl)-adenosine 5'-triphosphate triethylammonium salt Structural

What is 2'- and 3'-O-(4-Benzoylbenzoyl)-adenosine 5'-triphosphate triethylammonium salt?

The Uses of 2'- and 3'-O-(4-Benzoylbenzoyl)-adenosine 5'-triphosphate triethylammonium salt

2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate triethylammonium salt has been used as a P2X4 receptor agonist in rat kidney sections, type I diabetes induced rats and astrocyte?neuron coculture. It has also been used as a synthetic ATP analog in isotonic E3 medium.

What are the applications of Application

BzATP triethylammonium salt is a P2X7 receptor agonist

General Description

2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate is a photoreactive analog of ATP.

Biological Activity

Prototypic P2X 7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC 50 = 0.7 μ M in HEK 293 cells). Exhibits partial agonist activity at P2X 1 (pEC 50 = 8.7) and P2Y 1 receptors and can be used as a photoaffinity label for ATPase.

Biochem/physiol Actions

2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate triethylammonium salt is a selective purinergic receptor (P2X) agonist. It is more potent than ATP at homodimeric P2X7 receptors. It also effectively activates P2X1, P2X2, and P2X3 receptors. Useful as a photoaffinity label for proteins and enzymes that bind ATP.

Storage

-20°C

Properties of 2'- and 3'-O-(4-Benzoylbenzoyl)-adenosine 5'-triphosphate triethylammonium salt

storage temp.	-20°C
solubility	≤14 mg/ml in DMSO
form	solid
color	white to off-white
Water Solubility	Soluble in water (supplied pre-dissolved at a concentration of 5mM)

Safety information for 2'- and 3'-O-(4-Benzoylbenzoyl)-adenosine 5'-triphosphate triethylammonium salt

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2'- and 3'-O-(4-Benzoylbenzoyl)-adenosine 5'-triphosphate triethylammonium salt

InChIKey

HVOVBTNCGADRTH-WBLDMZOZSA-N

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