2-Aminopurine

Chemical properties

white to light yellow crystal powder

The Uses of 2-Aminopurine

2-Aminopurine has been used to inhibit eukaryotic initiation factor-2α (eIF2α)-phosphorylation of osteoarthritis (OA) chondrocytes.

The Uses of 2-Aminopurine

A probe of structural dynamicas and charge transfer in DNA

The Uses of 2-Aminopurine

A probe of structural dynamics and charge transfer in DNA .

What are the applications of Application

2-Aminopurine is An inhibitor of PKR.

Definition

ChEBI: The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position.

Biochem/physiol Actions

2-Aminopurine (2AP) is an analog of guanosine and adenosine, which can base pair with cytosine and thymine. It is used as a fluorescent probe in nucleic acid structure and dynamics. 2-Aminopurine (2-AP) inhibits double-stranded RNA-dependent protein kinase, protein kinase R (PKR).

Safety Profile

Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.