2-Aminopurine
Synonym(s):2-AP
- CAS NO.：452-06-2
- Empirical Formula: C5H5N5
- Molecular Weight: 135.13
- MDL number: MFCD00005566
- EINECS: 207-197-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:16:42
What is 2-Aminopurine?
Chemical properties
white to light yellow crystal powder
The Uses of 2-Aminopurine
2-Aminopurine has been used to inhibit eukaryotic initiation factor-2α (eIF2α)-phosphorylation of osteoarthritis (OA) chondrocytes.
The Uses of 2-Aminopurine
A probe of structural dynamicas and charge transfer in DNA
The Uses of 2-Aminopurine
A probe of structural dynamics and charge transfer in DNA .
What are the applications of Application
2-Aminopurine is An inhibitor of PKR.
Definition
ChEBI: The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position.
Biochem/physiol Actions
2-Aminopurine (2AP) is an analog of guanosine and adenosine, which can base pair with cytosine and thymine. It is used as a fluorescent probe in nucleic acid structure and dynamics. 2-Aminopurine (2-AP) inhibits double-stranded RNA-dependent protein kinase, protein kinase R (PKR).
Safety Profile
Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.
Properties of 2-Aminopurine
| Melting point: | 280-282 °C (lit.) |
| Boiling point: | 238.81°C (rough estimate) |
| Density | 1.3795 (rough estimate) |
| refractive index | 1.7000 (estimate) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acid (Slightly), Methanol (Slightly, Heated) |
| form | Amorphous Powder |
| pka | 8.02±0.20(Predicted) |
| color | Light beige |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 452-06-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Purine, 2-amino-(452-06-2) |
Safety information for 2-Aminopurine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for 2-Aminopurine
| InChIKey | MWBWWFOAEOYUST-UHFFFAOYSA-N |
New Products
Levothyroxine Impurity-F Montelukast EP Impurity-D/Montelukast USP Related Compound C Atorvastatin FXA Impurity/Atorvastatin Cyclic 6-Hydroxy Impurity Sodium Salt Isosulfan blue Keto N-Oxide Impurity Ivermectin Impurity F N-Nitroso des Methyl Tramadol/N-Nitroso-N-Desmethyl-Tramadol DL-beta-(3-Bromophenyl)alanine Tetrabutylammonium perchlorate N,O-Dimethylhydroxylamine hydrochloride (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) N,N CARBONYL DIIMIDAZOLE (R)-BoroLeu-(+)-Pinanediol-CF3COOH 1,4-bis(methylsulfonyl)butane 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzene CSA (DL-10-Camphorsulfonic Acid) 2-Hydroxy-4-methylnicotinic acid 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2S)-1-((2S,3S)-3-(2-methylbutyl)-4-oxooxetan-2-yl)pentadecan-2-yl formylleucinate 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethane-1-sulfonyl chloride S-(1-(3,5-dichlorophenyl)-2,2,2-trifluoroethyl) ethanethioateRelated products of tetrahydrofuran
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