2-Aminopurine
Synonym(s):2-AP
- CAS NO.：452-06-2
- Empirical Formula: C5H5N5
- Molecular Weight: 135.13
- MDL number: MFCD00005566
- EINECS: 207-197-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is 2-Aminopurine?
Chemical properties
white to light yellow crystal powder
The Uses of 2-Aminopurine
2-Aminopurine has been used to inhibit eukaryotic initiation factor-2α (eIF2α)-phosphorylation of osteoarthritis (OA) chondrocytes.
The Uses of 2-Aminopurine
A probe of structural dynamicas and charge transfer in DNA
The Uses of 2-Aminopurine
A probe of structural dynamics and charge transfer in DNA .
What are the applications of Application
2-Aminopurine is An inhibitor of PKR.
Definition
ChEBI: The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position.
Biochem/physiol Actions
2-Aminopurine (2AP) is an analog of guanosine and adenosine, which can base pair with cytosine and thymine. It is used as a fluorescent probe in nucleic acid structure and dynamics. 2-Aminopurine (2-AP) inhibits double-stranded RNA-dependent protein kinase, protein kinase R (PKR).
Safety Profile
Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.
Properties of 2-Aminopurine
| Melting point: | 280-282 °C (lit.) |
| Boiling point: | 238.81°C (rough estimate) |
| Density | 1.3795 (rough estimate) |
| refractive index | 1.7000 (estimate) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acid (Slightly), Methanol (Slightly, Heated) |
| form | Amorphous Powder |
| pka | 8.02±0.20(Predicted) |
| color | Light beige |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 452-06-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Purine, 2-amino-(452-06-2) |
Safety information for 2-Aminopurine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for 2-Aminopurine
| InChIKey | MWBWWFOAEOYUST-UHFFFAOYSA-N |
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