2-amino-4-phosphonobutyric acid
- CAS NO.：6323-99-5
- Empirical Formula: C4H10NO5P
- Molecular Weight: 183.1
- MDL number: MFCD00013999
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:07
What is 2-amino-4-phosphonobutyric acid?
Description
DL-AP4 is a broad-spectrum glutamatergic antagonist. DL-AP4 (2.5 mM) inhibits electrically stimulated synaptic transmission in rabbit hippocampal slices. It also depresses depolarizations induced by NMDA , L-homocysteate, or kainate in isolated frog spinal cord when used at a concentration of 1 mM. DL-AP4 (0.2 mM) inhibits the accumulation of inositol induced by ibotenate , quisqualate, L-glutamate, and L-aspartate in rat hippocampal slices.
The Uses of 2-amino-4-phosphonobutyric acid
DL-2-Amino-4-phosphonobutanoic acid (AP4) is an amino-acid derivative reported to block cone signals in the rat retina. Improves learning and memory processes in passive and active avoidance situations in rats.
Storage
Store at RT
Properties of 2-amino-4-phosphonobutyric acid
| Melting point: | 229-231 °C(Solv: ethanol (64-17-5); water (7732-18-5)) |
| Boiling point: | 491.7±55.0 °C(Predicted) |
| Density | 1.628±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Water:9.15(Max Conc. mg/mL);50.0(Max Conc. mM) |
| form | White solid. |
| pka | 2.19±0.10(Predicted) |
| Water Solubility | Soluble to 50 mM in water |
Safety information for 2-amino-4-phosphonobutyric acid
Computed Descriptors for 2-amino-4-phosphonobutyric acid
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