D-AP5

Synonym(s):D(−)-AP-5;D(−)-APV;D-2-Amino-5-phosphonovaleric acid;D-(–)-2-Amino-5-phosphonopentanoic Acid - CAS 79055-68-8 - Calbiochem;D-AP5, NMDA Antagonist II, APV, D-APV, 2-APV, D-2-amino-5-phosphonovalerate

CAS NO.：79055-68-8
Empirical Formula: C5H12NO5P
Molecular Weight: 197.13
MDL number: MFCD00078839
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-27 17:00:41

What is D-AP5?

Description

D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (K_d = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors. Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity. AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.

Chemical properties

white fine crystalline powder

The Uses of D-AP5

A competitive NMDA antagonist

What are the applications of Application

D(?)-2-Amino-5-phosphonovaleric acid (D-AP5) is a selective antagonist of the NMDA receptor

General Description

Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used competitive NMDA receptor antagonist.

Biological Activity

Widely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer (L-(+)-2-Amino-5-phosphonopentanoic acid ). Also available as part of the Mixed NMDA Receptor Tocriset™ .

Biochem/physiol Actions

Product does not compete with ATP.

Storage

Room temperature

Properties of D-AP5

Melting point:	approximate 233℃
Boiling point:	482.1±55.0 °C(Predicted)
Density	1.529±0.06 g/cm3(Predicted)
RTECS	RD2513000
storage temp.	Store at RT
solubility	Soluble to 100 mM in sterile
pka	2.46±0.10(Predicted)
form	White solid
color	White
Water Solubility	Soluble in water (100mM)
Sensitive	Light Sensitive

Safety information for D-AP5

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.