(R)-CPP
Synonym(s):R-(−)-3-(2-Carboxypiperazin-4-yl)propanephosphonic acid
- CAS NO.：126453-07-4
- Empirical Formula: C8H17N2O5P
- Molecular Weight: 252.2
- MDL number: MFCD00153786
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-16 07:06:08
What is (R)-CPP?
Description
(R)-CPP is an NMDA receptor antagonist (Ki = 0.14 μM). It binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits with Ki values of 0.04, 0.3, 0.6, and 2 μM, respectively. It inhibits depolarization induced by NMDA in isolated hemisected frog spinal cord (pA2 = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA2 = 6.2). (R)-CPP inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED50 = 65.8 μmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED50 = 127 μmol/kg).
The Uses of (R)-CPP
(R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism.
What are the applications of Application
(R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism
Biological Activity
Highly potent NMDA antagonist; more active isomer. Shows some selectivity for NR2A-containing receptors (K i values are 0.041, 0.27, 0.63 and 1.99 μ M for inhibition of NR2A-, NR2B-, NR2C- and NR2D-containing recombinant NMDA receptors respectively).
Storage
Room temperature (desiccate)
Properties of (R)-CPP
| Boiling point: | 546.7±60.0 °C(Predicted) |
| Density | 1.408±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at RT |
| solubility | Water: 100mM |
| pka | 1.89±0.20(Predicted) |
| form | White crystalline powder. |
| color | White to off-white |
| Water Solubility | Soluble to 100 mM in water |
Safety information for (R)-CPP
Computed Descriptors for (R)-CPP
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