2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
- CAS NO.：150493-34-8
- Empirical Formula: C15H11ClF3N3
- Molecular Weight: 325.72
- MDL number: MFCD00920837
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-10-29 15:43:00
What is 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole?
Biological Activity
NS-638 is a non-peptidic small molecule with Ca2+-ion channel blocking properties. The IC50 value for intracellular blocking of the increase in Ca2+ concentration activated by K+ was 3.4 μM.
in vivo
In the mouse middle cerebral artery occlusion model, NS-638 administered ip (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion.
Properties of 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
| Boiling point: | 476.3±55.0 °C(Predicted) |
| Density | 1.45±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol |
| form | A solid |
| pka | 5.15±0.10(Predicted) |
| color | White to off-white |
Safety information for 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
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