NS 1619

Synonym(s):1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one

CAS NO.：153587-01-0
Empirical Formula: C15H8F6N2O2
Molecular Weight: 362.23
MDL number: MFCD00928190
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-07 19:09:50

What is NS 1619?

The Uses of NS 1619

NS 1619 is a large conductance calcium-activated potassium channels (BKCa) activator and has been shown to induce precondition in the heart.

What are the applications of Application

NS-1619 is a selective large conductance calcium activated potassium channel activator

Definition

ChEBI: A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It i an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).

Biochem/physiol Actions

NS 1619 is a selective large conductance Ca2+-activated K+-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury.

Storage

+4°C

Properties of NS 1619

Density	1.563±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL
form	solid
pka	8.32±0.48(Predicted)
color	white

Safety information for NS 1619

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.