1-ACETYLINDOLE
Synonym(s):NSC 521758
- CAS NO.：576-15-8
- Empirical Formula: C10H9NO
- Molecular Weight: 159.18
- MDL number: MFCD00038005
- EINECS: 209-396-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:51
What is 1-ACETYLINDOLE?
Chemical properties
clear yellow liquid after melting
The Uses of 1-ACETYLINDOLE
1-Acetylindole may be used in the stereocontrolled synthesis of (±)-geissoschizine. It may be used in the preparation of (1-acetyl-κO-indolyl-κC2)tetracarbonylmanganese, via a standard cyclomanganation procedure.
Definition
ChEBI: N-Acetylindole is a member of indoles.
Synthesis Reference(s)
Tetrahedron Letters, 29, p. 2151, 1988 DOI: 10.1016/S0040-4039(00)86696-4
General Description
Quantum chemical calculations of ground state energy, geometrical structure and vibrational wavenumbers of 1-acetylindole has been carried out using density functional (DFT/B3LYP) method. Regioselective acylations of 1-acetylindole (N-acetylindole) under Friedel-Crafts reaction has been reported. Reaction of 1-acetylindole with manganese(III) acetate in the presence of malonic acid, is reported to afford 4-acetyl-3,3a,4,8b-tetrahydro-2H-furo[3,2-b]indol-2-one.
Properties of 1-ACETYLINDOLE
| Melting point: | 189 °C |
| Boiling point: | 123-125 °C/8 mmHg (lit.) |
| Density | 1.387 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| Odor | at 0.10?%?in?dipropylene glycol. floral |
| CAS DataBase Reference | 576-15-8(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Indole, 1-acetyl- (576-15-8) |
Safety information for 1-ACETYLINDOLE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-ACETYLINDOLE
1-ACETYLINDOLE manufacturer
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