ZPCK
Synonym(s):N-Carbobenzyloxy-L -phenylalanyl chloromethyl ketone;NSC 251810;SL-01;ZPCK
- CAS NO.：26049-94-5
- Empirical Formula: C18H18ClNO3
- Molecular Weight: 331.79
- MDL number: MFCD00037114
- EINECS: 247-432-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-12 18:10:29
What is ZPCK?
Description
SL-01 (26049-94-5) inhibits the p53-MDM2 interaction (20 μM). Has also been shown to inhibit bovine chymotrypsin A-γ.
Chemical properties
white powder
The Uses of ZPCK
SL 01 is a prodrug of gemcitabine , the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability. SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT-116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis. In nude mice bearing NCI-H460, HCT-116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth.
The Uses of ZPCK
Enzyme inhibitor.
The Uses of ZPCK
ZPCK's a peptidase from baker's yeast,and it is with esterase activities of carboxypeptidase Y.
References
1) Li et al. (2011), A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53-MDM2 interaction; J. Biomol. Screening, 16 450
Properties of ZPCK
| Melting point: | 107-108 °C(lit.) |
| Boiling point: | 503.1±50.0 °C(Predicted) |
| Density | 1.1630 (rough estimate) |
| refractive index | 1.6470 (estimate) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming). |
| form | solid |
| pka | 10.74±0.46(Predicted) |
| color | White |
| optical activity | [α]23/D +30°, c = 1 in chloroform |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| CAS DataBase Reference | 26049-94-5 |
| EPA Substance Registry System | Benzyl [(1S)-3-chloro-2-oxo-1-benzylpropyl]carbamate (26049-94-5) |
Safety information for ZPCK
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ZPCK
New Products
Cyclopentane-1,2-dione 2,6-Dibromoaniline 5-Hydroxy-3,9-dimethyl-7H-benzo[c]fluoren-7-one Methyl 4-(acetyloxy)-6-methoxy-1-(4-methoxyphenyl)-2naphthalenecarboxylate 4-Hydroxy-6,7-dimethoxy-1-phenyl-2naphthalenecarboxylic acid (3,5-Dibromophenyl)[4-(trifluoromethyl)phenyl]methanone (4-butoxyphenyl)(4-fluorophenyl)methanone (4-Bromophenyl)(3,4-dimethoxyphenyl)methanone Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide 4-Ethyl-4-hydroxy-1,4,7,8-tetrahydro-3H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolane]-3,10-dione (E)-N'-(2-cyano-4-nitrophenyl)- N,N-dimethylformimidamide 2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid Benzyl-N,4-dimethylpiperidine-3- amine dihydrochloride 5-bromopyridin-2-amine 2-Chloro Benzylcyanide 3,4 Diethoxy Benzylcyanide 3-chlorobenzyl cyanide 3,4 Dimethoxy BenzylcyanideRelated products of tetrahydrofuran
You may like
-
Z-Phe-CMK 98.00% CAS 26049-94-5View Details
26049-94-5 -
Z-L-Phe chloromethyl ketone CAS 26049-94-5View Details
26049-94-5 -
151239-47-3 98+View Details
151239-47-3 -
4-Hydroxy-6-methyl-1-(4-methylphenyl)-2naphthalenecarboxylic acid 98+View Details
101894-09-1 -
83883-25-4 98+View Details
83883-25-4 -
(3,5-dibromophenyl)(4-methoxyphenyl)methanone 1991533-97-1 98+View Details
1991533-97-1 -
54598-15-1 4,5,7-Trimethyl-2(1H)-quinolinone 98+View Details
54598-15-1 -
4-(6-HYDROXYHEXYLOXY)BENZOIC ACID 83883-25-4 98+View Details
83883-25-4
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.