ZPCK
Synonym(s):N-Carbobenzyloxy-L -phenylalanyl chloromethyl ketone;NSC 251810;SL-01;ZPCK
- CAS NO.：26049-94-5
- Empirical Formula: C18H18ClNO3
- Molecular Weight: 331.79
- MDL number: MFCD00037114
- EINECS: 247-432-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-12 18:10:29
What is ZPCK?
Description
SL-01 (26049-94-5) inhibits the p53-MDM2 interaction (20 μM). Has also been shown to inhibit bovine chymotrypsin A-γ.
Chemical properties
white powder
The Uses of ZPCK
ZPCK's a peptidase from baker's yeast,and it is with esterase activities of carboxypeptidase Y.
The Uses of ZPCK
SL 01 is a prodrug of gemcitabine , the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability. SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT-116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis. In nude mice bearing NCI-H460, HCT-116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth.
The Uses of ZPCK
Enzyme inhibitor.
References
1) Li et al. (2011), A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53-MDM2 interaction; J. Biomol. Screening, 16 450
Properties of ZPCK
| Melting point: | 107-108 °C(lit.) |
| Boiling point: | 503.1±50.0 °C(Predicted) |
| Density | 1.1630 (rough estimate) |
| refractive index | 1.6470 (estimate) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming). |
| form | solid |
| pka | 10.74±0.46(Predicted) |
| color | White |
| optical activity | [α]23/D +30°, c = 1 in chloroform |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| CAS DataBase Reference | 26049-94-5 |
| EPA Substance Registry System | Benzyl [(1S)-3-chloro-2-oxo-1-benzylpropyl]carbamate (26049-94-5) |
Safety information for ZPCK
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ZPCK
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