ZM 336372

Synonym(s):3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide;N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide;ZM 336372 - CAS 208260-29-1 - Calbiochem

CAS NO.：208260-29-1
Empirical Formula: C23H23N3O3
Molecular Weight: 389.45
MDL number: MFCD02683971
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:23:14

What is ZM 336372?

Description

The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC₅₀ = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells. Activation of the Raf-1 signalling pathway using ZM 336372 in human carcinoid tumor cells results in induction of cell cycle inhibitors and suppression of cellular proliferation.

The Uses of ZM 336372

It is small molecule tyrosine kinase modulator.

The Uses of ZM 336372

It is small molecule tyrosine kinase modulator. ZM336372 induces apoptosis associated with phosphorylation of GSK-3β in pancreatic adenocarcinoma cell lines.

What are the applications of Application

ZM 336372 is a potent and selective Raf-1 inhibitor

Definition

ChEBI: 3-(dimethylamino)-N-[3-[[(4-hydroxyphenyl)-oxomethyl]amino]-4-methylphenyl]benzamide is a member of benzamides.

References

1) Hall-Jackson et al. (1999), Paradoxical activation of Raf by a novel Raf inhibitor; Chem. Biol., 6 559 2) Deming et al. (2010), ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines; J. Surg. Res., 161 28

Properties of ZM 336372

Boiling point:	484.4±45.0 °C(Predicted)
Density	1.298
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO: >5mg/mL (warmed)
form	powder
pka	8.31±0.15(Predicted)
color	white to beige
Sensitive	Light Sensitive
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety information for ZM 336372

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H317:Sensitisation, Skin H413:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.