ZONIPORIDE
Synonym(s):N-(Aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide hydrochloride hydrate
- CAS NO.：241800-98-6
- Empirical Formula: C17H16N6O
- Molecular Weight: 320.35
- MDL number: MFCD04113213
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 17:23:47
What is ZONIPORIDE?
The Uses of ZONIPORIDE
Zoniporide hydrochloride hydrate has been used for the inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1) in rat models. It has also been used in cytotoxicity assay and to study its effect on lymphocytic choriomeningitis virus multiplication.
Biochem/physiol Actions
Zoniporide is a potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1). IC50 = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na+ update with IC50 of 14 nM.
Properties of ZONIPORIDE
| Density | 1.54 |
| storage temp. | 2-8°C |
| solubility | H2O: soluble2mg/mL, clear (warmed) |
| form | powder |
| pka | 11.44±0.46(Predicted) |
| color | white to tan |
Safety information for ZONIPORIDE
Computed Descriptors for ZONIPORIDE
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