ZK 200775
- CAS NO.：161605-73-8
- Empirical Formula: C14H15F3N3O6P
- Molecular Weight: 409.25
- MDL number: MFCD07364000
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-04-17 18:22:24
What is ZK 200775?
The Uses of ZK 200775
ZK 200775 is a competitive AMPA/kainate antagonist. Neuronal protection against cerebral ischemia.
What are the applications of Application
ZK 200775 is a competitive AMPA/kainate antagonist
Biological Activity
Competitive AMPA/kainate antagonist. In rat cortical membranes, displays high affinity for [ 3 H]-AMPA (K i = 120 nM) and [ 3 H]-CNQX (K i = 32 nM) binding sites and low affinity for kainate and NMDA channel-associated binding sites (IC 50 values range from 2.5 to 11 μ M). Inhibits currents induced by AMPA, kainate and NMDA with IC 50 values of 21 nM, 27 nM, and > 1 μ M respectively. Displays anxiolytic, anticonvulsant and muscle relaxant activity in vivo .
Storage
Desiccate at +4°C
Properties of ZK 200775
| Density | 1.615±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: ≥20mg/mL |
| pka | 2.09±0.10(Predicted) |
| form | powder |
| color | off-white to light brown |
Safety information for ZK 200775
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ZK 200775
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