Zipeprol dihydrochloride

Originator

Respilene,Winthrop,France,1973

The Uses of Zipeprol dihydrochloride

Zipeprol dihydrochloride is a piperazine ethanol derivative that is a widely used pediatric antitussive. Zipeprol dihydrochloride has cytotoxic and immunomodulative effects on human peripheral blood lymphocytes. Zipeprol dihydrochloride has a novel spectrum of action involving opioid and non-opioid effects with possible abuse potential.

Manufacturing Process

In a reactor provided with a mechanical stirrer, a reflux refrigerant and a thermometer, there is introduced: 393 grams 1-[2-phenyl, 2-methoxy]ethyl piperazine and 22 grams 3-phenyl-3-methoxy propylene oxide in 750 ml of absolute ethanol.
When the slightly exothermic reaction (rise in temperature of about 20°C) has ceased, heating is effected for 1.5 hours at 60°C. The product is then cooled to 4°C and left to crystallize for about 12 hours. The precipitate is centrifugated then recrystallized in 500 ml of absolute ethanol.
420 grams of the desired compound is thus obtained in the form of a white, crystalline powder, melting point 83°C.

Therapeutic Function

Bronchodilator